Effect of Plaque Volume on Subsequent Vessel Remodeling at Edges of Sirolimus-Eluting Stents

Serial (baseline and 9-month follow-up) intravascular ultrasound analysis was performed at 5-mm reference segments immediately proximal and distal to the sirolimus-eluting stent (SES) in 33 lesions. Proximal and distal reference segments were divided into 1-mm subsegments. Between postintervention a...

Full description

Saved in:
Bibliographic Details
Published in:The American journal of cardiology 2006-10, Vol.98 (8), p.1041-1044
Main Authors: Asano, Tatsuhiko, Kobayashi, Yoshio, Mintz, Gary S., Ishio, Naoki, Fujimaki, Shigenori, Ogawa, Yasuhide, Nakayama, Takashi, Kuroda, Nakabumi, Komuro, Issei
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Cardiology
Cardiology. Vascular system
Coronary Angiography
Coronary Disease - therapy
Coronary Restenosis - prevention & control
Coronary vessels
Coronary Vessels - pathology
Coronary Vessels - physiology
Female
Follow-Up Studies
Humans
Male
Medical sciences
Regression Analysis
Risk factors
Sirolimus - administration & dosage
Stents
Treatment Outcome
Ultrasonic imaging
Ultrasonography, Interventional
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Serial (baseline and 9-month follow-up) intravascular ultrasound analysis was performed at 5-mm reference segments immediately proximal and distal to the sirolimus-eluting stent (SES) in 33 lesions. Proximal and distal reference segments were divided into 1-mm subsegments. Between postintervention and follow-up intravascular ultrasound studies, there were significant decreases in the lumen and increases in plaque & media areas in the subsegment closest to the distal edge, with no change in external elastic membrane area. There was no significant change in external elastic membrane, lumen, and plaque & media areas within the other subsegments. At the nearest 1-mm subsegment from the proximal and distal edges, baseline plaque & media area was associated with subsequent vessel remodeling. In conclusion, a large amount of plaque at the SES edge may be a risk of negative remodeling at follow-up (stent edge restenosis). It supports the importance of “normal-to-normal” SES deployment.
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2006.05.021