Immunostimulatory CpG oligodeoxynucleotides enhance the induction of bovine CD4 + cytotoxic T-lymphocyte responses against the polymorphic immunodominant molecule of the protozoan parasite Theileria parva

Enhancement of the induction of cytotoxic T-cell responses by immunostimulatory CpG oligodeoxynucleotides has been described in humans and mouse models. The present study attempted to address whether CpG has a similar effect in cattle. Immunisation of cattle with a recombinant form of the polymorphi...

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Bibliographic Details
Published in:Veterinary immunology and immunopathology 2007-02, Vol.115 (3), p.383-389
Main Authors: Graham, Simon P., Saya, Rosemary, Awino, Elias, Ngugi, Daniel, Nyanjui, John K., Hecker, Rolf, Taracha, Evans L.N., Nene, Vishvanath
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic - pharmacology
Amino Acid Sequence
Animals
Antibodies, Protozoan - blood
ANTIGENS
Antigens, Protozoan - genetics
Antigens, Protozoan - immunology
Antigens, Protozoan - pharmacology
Cattle
CATTLE [BOVINAE]
CD4-Positive T-Lymphocytes - drug effects
CD4-Positive T-Lymphocytes - immunology
CpG
Cytotoxic T lymphocytes
Enzyme-Linked Immunosorbent Assay - veterinary
Flow Cytometry - veterinary
Immunization - veterinary
IMMUNOLOGY
IMMUNOSTIMULANTS
Interferon-gamma - immunology
Lymphocyte Activation
LYMPHOCYTES
Male
Molecular Sequence Data
Oligodeoxyribonucleotides - pharmacology
Protozoan Proteins - genetics
Protozoan Proteins - immunology
Protozoan Proteins - pharmacology
Recombinant Fusion Proteins - genetics
Recombinant Fusion Proteins - immunology
Recombinant Fusion Proteins - pharmacology
T-Lymphocytes, Cytotoxic - drug effects
T-Lymphocytes, Cytotoxic - immunology
THEILERIA PARVA
Theileria parva - immunology
Theileriasis - immunology
TOXICITY
VACCINATION
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Summary:Enhancement of the induction of cytotoxic T-cell responses by immunostimulatory CpG oligodeoxynucleotides has been described in humans and mouse models. The present study attempted to address whether CpG has a similar effect in cattle. Immunisation of cattle with a recombinant form of the polymorphic immunodominant molecule from Theileria parva emulsified with immunostimulatory CpG oligodeoxynucleotides in adjuvant had no effect on the induction of antibody responses including the isotype profile, but significantly enhanced the induction of cytolytic responses that were mediated by CD4 +CD3 + T cells utilizing the perforin-granzyme pathway.
ISSN:0165-2427
1873-2534
DOI:10.1016/j.vetimm.2006.11.010