IL-12 Rapidly Alters the Functional Profile of Tumor-Associated and Tumor-Infiltrating Macrophages In Vitro and In Vivo

Tumor-associated macrophages (TAMs) play a major role in promoting tumor growth and metastasis and in suppressing the antitumor immune response. Despite the immunosuppressive environment created by the tumor and enforced by tumor-associated macrophages, treatment of tumor-bearing mice with IL-12 ind...

Full description

Saved in:
Bibliographic Details
Published in:Journal of Immunology 2007-02, Vol.178 (3), p.1357-1362
Main Authors: Watkins, Stephanie K, Egilmez, Nejat K, Suttles, Jill, Stout, Robert D
Format: Article
Language:English
Subjects:
Animals
Carcinoma, Lewis Lung - immunology
Cell Movement - immunology
Cytokines - biosynthesis
Inflammation - immunology
Interleukin-12 - pharmacology
Interleukin-12 - therapeutic use
Macrophages - drug effects
Macrophages - immunology
Mice
Mice, Inbred C57BL
Neoplasms - immunology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Tumor-associated macrophages (TAMs) play a major role in promoting tumor growth and metastasis and in suppressing the antitumor immune response. Despite the immunosuppressive environment created by the tumor and enforced by tumor-associated macrophages, treatment of tumor-bearing mice with IL-12 induces tumor regression associated with appearance of activated NK cells and activated tumor-specific CTLs. We therefore tested the hypothesis that IL-12 treatment could alter the function of these tumor-associated suppressor macrophages. Analysis of tumor-infiltrating macrophages and distal TAMs revealed that IL-12, both in vivo and in vitro, induced a rapid (
ISSN:0022-1767
1550-6606
1365-2567
DOI:10.4049/jimmunol.178.3.1357