Interleukin-1 contributes to an effective clearance of Mycobacterium kansasii from the respiratory tract

Mycobacterium kansasii is an emerging pathogen that is able to induce pulmonary disease resembling tuberculosis. To determine the role of interleukin (IL-)1 in lung infection caused by this atypical mycobacterium, IL-1 receptor type 1 knockout (IL-1R 1 KO) and normal wild type mice were intranasally...

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Bibliographic Details
Published in:Microbes and infection 2006-08, Vol.8 (9), p.2409-2413
Main Authors: Wieland, Catharina W., Florquin, Sandrine, Pater, Jennie M., Weijer, Sebastiaan, van der Poll, Tom
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Humans
Infection
Innate
Interleukin-1
Interleukin-1 - immunology
Lung
Lung - immunology
Mice
Mice, Inbred C57BL
Mice, Knockout
Microbiology
Mycobacterium
Mycobacterium Infections, Nontuberculous - immunology
Mycobacterium Infections, Nontuberculous - microbiology
Mycobacterium kansasii
Mycobacterium kansasii - immunology
Pneumonia, Bacterial - immunology
Pneumonia, Bacterial - microbiology
Receptors, Interleukin-1 Type I - deficiency
Receptors, Interleukin-1 Type I - genetics
Receptors, Interleukin-1 Type I - immunology
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Summary:Mycobacterium kansasii is an emerging pathogen that is able to induce pulmonary disease resembling tuberculosis. To determine the role of interleukin (IL-)1 in lung infection caused by this atypical mycobacterium, IL-1 receptor type 1 knockout (IL-1R 1 KO) and normal wild type mice were intranasally infected with M. kansasii. IL-1R 1 KO mice demonstrated a reduced antibacterial response in the lungs and an increased dissemination to the liver, which was accompanied by an enhanced pulmonary inflammatory response. These data identify IL-1 as an important component of the innate immune response to lung infection by M. kansasii.
ISSN:1286-4579
1769-714X
DOI:10.1016/j.micinf.2006.05.002