Molecular and parametric imaging with iron oxides

Superparamagnetic iron oxide (SPIO) contrast agents, clinically established for high resolution magnetic resonance imaging of reticuloendothelial system containing anatomical structures, can additionally be exploited for the non-invasive characterization and quantification of pathology down to the m...

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Bibliographic Details
Published in:Radiologe 2007-01, Vol.47 (1), p.34-42
Main Authors: Matuszewski, L, Tombach, B, Heindel, W, Bremer, C
Format: Article
Language:ger
Subjects:
Cell Separation - methods
Contrast Media
Ferric Compounds - metabolism
Magnetic Resonance Imaging - methods
Molecular Probe Techniques
Online Access:Get full text
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Summary:Superparamagnetic iron oxide (SPIO) contrast agents, clinically established for high resolution magnetic resonance imaging of reticuloendothelial system containing anatomical structures, can additionally be exploited for the non-invasive characterization and quantification of pathology down to the molecular level. In this context, SPIOs can be applied for non-invasive cell tracking, quantification of tissue perfusion and target specific imaging, as well as for the detection of gene expression. This article provides an overview of new applications for clinically approved iron oxides as well of new, modified SPIO contrast agents for parametric and molecular imaging.
ISSN:0033-832X
DOI:10.1007/s00117-006-1451-y