Autophagy in MHC Class II Presentation: Sampling from Within

MHC class II molecules usually present exogenous antigens, but peptidome analyses have also identified many antigens from cytosolic or nuclear sources. In this issue of Immunity, Schmid et al. (2007) show that MHC class II molecules can present these through autophagosomes.

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Bibliographic Details
Published in:Immunity (Cambridge, Mass.) Mass.), 2007, Vol.26 (1), p.1-3
Main Authors: Menéndez-Benito, Victoria, Neefjes, Jacques
Format: Article
Language:English
Subjects:
Animals
Antigen Presentation - immunology
Autophagy
Autophagy - immunology
Biosynthesis
Enzymes
Histocompatibility Antigens Class II - immunology
Humans
Peptides
Phagosomes - immunology
Proteins
Women
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Description
Summary:MHC class II molecules usually present exogenous antigens, but peptidome analyses have also identified many antigens from cytosolic or nuclear sources. In this issue of Immunity, Schmid et al. (2007) show that MHC class II molecules can present these through autophagosomes.
ISSN:1074-7613
1097-4180
DOI:10.1016/j.immuni.2007.01.005