In Vivo Molecular Probing of Cellular Compartments with Gold Nanoparticles and Nanoaggregates

Surface-enhanced Raman (SERS) signatures were measured from single living cells at different times after the uptake of gold nanoparticles. The spectra are indicative of chemical changes in the environment of the nanostructures over time. The increase of the SERS signal strength and parallel TEM stud...

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Bibliographic Details
Published in:Nano letters 2006-10, Vol.6 (10), p.2225-2231
Main Authors: Kneipp, Janina, Kneipp, Harald, McLaughlin, Margaret, Brown, Dennis, Kneipp, Katrin
Format: Article
Language:English
Subjects:
Animals
Cell Line
Cross-disciplinary physics: materials science
rheology
Endocytosis - physiology
Exact sciences and technology
Gold - chemistry
Macrophages - cytology
Macrophages - physiology
Materials science
Materials Testing
Mice
Molecular Probe Techniques
Nanopowders
Nanoscale materials and structures: fabrication and characterization
Nanostructures - chemistry
Nanostructures - ultrastructure
Physics
Spectrum Analysis, Raman - methods
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Summary:Surface-enhanced Raman (SERS) signatures were measured from single living cells at different times after the uptake of gold nanoparticles. The spectra are indicative of chemical changes in the environment of the nanostructures over time. The increase of the SERS signal strength and parallel TEM studies indicate the formation of nanoaggregates providing optimum SERS enhancement for ultrasensitive probing inside the endosomal compartment. The results have implications for medical and biotechnology applications of SERS nanosensors in cells.
ISSN:1530-6984
1530-6992
DOI:10.1021/nl061517x