Bioactive Bibenzyl Derivatives and Fluorenones from Dendrobium nobile

Bioassay-guided fractionation of the 60% ethanol extract of the stems of Dendrobium nobile using the DPPH assay led to the isolation of two new bibenzyl derivatives, nobilin D (1) and nobilin E (2), and a new fluorenone, nobilone (3), together with seven known compounds (4−10). Their structures were...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2007-01, Vol.70 (1), p.24-28
Main Authors: Zhang, Xue, Xu, Jie-Kun, Wang, Jue, Wang, Nai-Li, Kurihara, Hiroshi, Kitanaka, Sumumu, Yao, Xin-Sheng
Format: Article
Language:English
Subjects:
antioxidant activity
Antioxidants - chemistry
Antioxidants - isolation & purification
Antioxidants - pharmacology
Bibenzyls - chemistry
Bibenzyls - isolation & purification
Bibenzyls - pharmacology
Biological and medical sciences
Biphenyl Compounds
chemical structure
Dendrobium
Dendrobium - chemistry
Dendrobium nobile
Drugs, Chinese Herbal - chemistry
Drugs, Chinese Herbal - isolation & purification
Drugs, Chinese Herbal - pharmacology
enzyme inhibition
Fluorenes - chemistry
Fluorenes - isolation & purification
Fluorenes - pharmacology
fluorenone
General pharmacology
Medical sciences
medicinal plants
Nitric Oxide - biosynthesis
Nitric Oxide - metabolism
nitric oxide synthase
nobilin
nobilone
Orchidaceae
Oriental traditional medicine
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
phytochemicals
Picrates - pharmacology
Plant Stems - chemistry
Plants, Medicinal - chemistry
polycyclic aromatic hydrocarbons
Sesquiterpenes, Germacrane
spectral analysis
Stilbenes - pharmacology
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Summary:Bioassay-guided fractionation of the 60% ethanol extract of the stems of Dendrobium nobile using the DPPH assay led to the isolation of two new bibenzyl derivatives, nobilin D (1) and nobilin E (2), and a new fluorenone, nobilone (3), together with seven known compounds (4−10). Their structures were determined on the basis of spectroscopic analyses. Compounds 1, 2, 4, 7, 8, and 10 exhibited significant antioxidant activity higher than or equivalent to vitamin C in the DPPH assay, and compounds 1, 3, 4, and 7−10 displayed higher antioxidant activity than vitamin C in the ORAC assay. Compounds 1, 2, and 10 also exhibited stronger inhibitory effects on NO production than resveratrol.
ISSN:0163-3864
1520-6025
DOI:10.1021/np060449r