Iridoids from Crescentia alata

• Published in: Journal of natural products (Washington, D.C.) D.C.), 2007-01, Vol.70 (1), p.100-102
• Main Authors: Valladares, María Guadalupe, Rios, María Yolanda
• Format: Article
• Language: English
• Subjects: Bignoniaceae; Bignoniaceae - chemistry; Biological and medical sciences; chemical structure; Crescentia; Crescentia alata; Crystallography, X-Ray; General pharmacology; iridoids; Iridoids - chemistry; Iridoids - isolation & purification; Medical sciences; medicinal plants; Mexico; Molecular Conformation; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plants, Medicinal - chemistry; spectral analysis; traditional medicine
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np060499w

Four new 11-nor-iridoids, 6β,7β,8α,10-tetrahydroxy-cis-2-oxabicyclo[4.3.0]nonan-3-one (1), 6β,7β,8α,10-tetra-p-hydroxybenzoyl-cis-2-oxabicyclo[4.3.0]nonan-3-one (2), 1β,6β,7α,8α,10-pentahydroxy-cis-2-oxabicyclo[4.3.0]nonane (3), and 6β-hydroxy-2-oxabicyclo[4.3.0]Δ − -nonen-1-one (4), were isolated from the pulp of the fruits of Crescentia alata. Although a limited number of Crescentia species have been studied chemically, iridoids lacking C-11 have been isolated from the fruits of these species, and the isolation of compounds 1−4 from C. alata is in accordance with the constituents of the species previously analyzed. The structures of these compounds were established on the basis of IR, UV, 1H and 13C NMR, DEPT, COSY, HSQC, HMBC, MS, and X-ray data.