Successful weight maintenance preserves lower levels of oxidized LDL achieved by weight reduction in obese men

Objective: We studied the association between weight maintenance, oxidized low-density lipoprotein (ox-LDL) and other lipoproteins in obese men. Methods: A 2-month weight reduction phase (WRP) with a very-low-energy diet was followed by a 6-month weight maintenance period and an unsupervised 2-year...

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Bibliographic Details
Published in:International Journal of Obesity 2007-02, Vol.31 (2), p.245-253
Main Authors: Linna, M.S, Borg, P, Kukkonen-Harjula, K, Fogelholm, M, Nenonen, A, Ahotupa, M, Vasankari, T.J
Format: Article
Language:English
Subjects:
Adult
Atherosclerosis
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
Blood Glucose - metabolism
blood lipids
Blood Pressure
Body Composition
Body Weight
Calories
Cardiology. Vascular system
Cardiovascular disease
cardiovascular diseases
Care and treatment
Complications and side effects
dienoic fatty acids
Diet
Epidemiology
Fads
Fasting - blood
Feeding. Feeding behavior
Follow-Up Studies
Fundamental and applied biological sciences. Psychology
Health aspects
Health Promotion and Disease Prevention
Humans
Internal Medicine
lipid peroxidation
Lipids
Lipids - blood
Lipoproteins
Lipoproteins, LDL - blood
low density lipoprotein
Low density lipoproteins
Male
Medical research
Medical sciences
Medicine
Medicine & Public Health
men
Metabolic Diseases
Middle Aged
Obesity
Obesity - blood
Obesity - diet therapy
Obesity - physiopathology
original-article
Oxidation
Oxidation-Reduction
Physiology
Prevention
Public Health
Risk factors
Risk reduction
Strength training
Vertebrates: anatomy and physiology, studies on body, several organs or systems
very low calorie diet
weight control
Weight Loss
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Summary:Objective: We studied the association between weight maintenance, oxidized low-density lipoprotein (ox-LDL) and other lipoproteins in obese men. Methods: A 2-month weight reduction phase (WRP) with a very-low-energy diet was followed by a 6-month weight maintenance period and an unsupervised 2-year follow-up. Ninety men entered and 68 (76%) completed the study. Subjects were analyzed as one group and after division into two subgroups: 20 most successful men in maintaining the lost weight (subgroup 1) and the remaining (n=48) men (subgroup 2). Ox-LDL was measured by quantifying the amount of conjugated dienes in LDL particles. Results: The mean (+/-s.d.) weight reduction at the end of the WRP (n=68) was 14% (confidence interval (CI) 12.9-14.7%, 14.5+/-4.2 kg, P
ISSN:0307-0565
1476-5497
DOI:10.1038/sj.ijo.0803413