Noninvasive tests for the prediction of significant hepatic fibrosis in hepatitis C virus carriers with persistently normal alanine aminotransferases

: Background: The diagnostic value of Doppler and various noninvasive indices in predicting significant hepatic fibrosis in hepatitis C virus (HCV) carriers with persistently normal alanine aminotransferases (PNALT) is unknown. Methods: Seventy‐nine treatment‐naïve HCV carriers with PNALT, who recei...

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Bibliographic Details
Published in:Liver international 2006-11, Vol.26 (9), p.1087-1094
Main Authors: Liu, Chen-Hua, Lin, Jou-Wei, Tsai, Feng-Chiao, Yang, Pei-Ming, Lai, Ming-Yang, Chen, Jun-Herng, Kao, Jia-Horng, Chen, Ding-Shinn
Format: Article
Language:English
Subjects:
Adult
Aging - blood
Alanine Transaminase - blood
Aspartate Aminotransferases - blood
Carrier State
chronic hepatitis C
duplex Doppler ultrasonography
Female
hepatic fibrosis
Hepatitis C - blood
Hepatitis C - complications
Hepatitis C - diagnosis
Hepatitis C - physiopathology
Hepatitis C virus
Humans
Liver Cirrhosis - virology
Male
Middle Aged
noninvasive test
persistent normal alanine aminotransferase
Platelet Count
Predictive Value of Tests
Pulse
Sensitivity and Specificity
splenic arterial pulsatility index
Splenic Artery - diagnostic imaging
Splenic Artery - physiopathology
Ultrasonography
Ultrasonography, Doppler
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Summary:: Background: The diagnostic value of Doppler and various noninvasive indices in predicting significant hepatic fibrosis in hepatitis C virus (HCV) carriers with persistently normal alanine aminotransferases (PNALT) is unknown. Methods: Seventy‐nine treatment‐naïve HCV carriers with PNALT, who received Doppler ultrasonography and percutaneous liver biopsies, were enrolled in the study. Doppler indices, including portal vein velocity (PVV), hepatic arterial resistive index (HARI), hepatic arterial pulsatility index (HAPI), splenic arterial resistive index (SARI), and splenic arterial pulsatility index (SAPI), were compared with known biochemical indices used in HCV carriers with elevated ALT levels, including aspartate aminotransferase (AST) to platelet ratio index (APRI), age‐platelet index (API), and AST to ALT ratio (AAR), for the diagnostic accuracy of significant hepatic fibrosis. Results: SAPI was the most discriminatory index among the Doppler indices (P
ISSN:1478-3223
1478-3231
DOI:10.1111/j.1478-3231.2006.01355.x