Differential effects of low and high doses of topiramate on consolidation and retrieval of novel object recognition memory in rats

Abstract Topiramate is a new antiepileptic drug proposed to facilitate synaptic inhibition and block excitatory receptors. However, little is known about the effects of topiramate on memory. In the first experiment, intraperitoneal injection of topiramate at doses of 10.0 and 100.0 mg/kg, immediatel...

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Bibliographic Details
Published in:Epilepsy & behavior 2007-02, Vol.10 (1), p.32-37
Main Authors: Martins de Lima, Maria Noemia, Presti-Torres, Juliana, Dornelles, Arethuza, Bromberg, Elke, Schröder, Nadja
Format: Article
Language:English
Subjects:
Animals
Anticonvulsant drugs
Anticonvulsants - pharmacology
Behavior, Animal - drug effects
Dose-Response Relationship, Drug
Epilepsy
Exploratory Behavior - drug effects
Female
Fructose - analogs & derivatives
Fructose - pharmacology
Injections, Intraperitoneal
Memory consolidation
Memory retrieval
Mental Recall - drug effects
Neurology
Object recognition
Rats
Rats, Wistar
Recognition (Psychology) - drug effects
Recognition memory
Retention (Psychology) - drug effects
Statistics, Nonparametric
Topiramate
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Summary:Abstract Topiramate is a new antiepileptic drug proposed to facilitate synaptic inhibition and block excitatory receptors. However, little is known about the effects of topiramate on memory. In the first experiment, intraperitoneal injection of topiramate at doses of 10.0 and 100.0 mg/kg, immediately after training, induced a deficit in short-term memory (STM) of a novel object recognition (NOR) task tested 1.5 hours after training in rats. In a long-term memory (LTM) test given to the same rats 24 hours after training, topiramate 0.1 mg/kg enhanced, whereas 10.0 and 100.0 mg/kg impaired, NOR retention. In the second experiment, administration of topiramate 0.01 and 0.10 mg/kg 1 hour prior to the LTM retention test improved NOR retention, whereas 10.0 and 100.0 mg/kg produced retrieval deficits. The results indicate that low doses of topiramate improve, whereas high doses impair, consolidation and retrieval of recognition memory in rats.
ISSN:1525-5050
1525-5069
DOI:10.1016/j.yebeh.2006.09.007