Elevated Serum Homocysteine, Low Serum Vitamin B12, Folate, and Age-related Macular Degeneration: The Blue Mountains Eye Study

Purpose To assess associations between increased serum homocysteine, low vitamin B12, low folate, and age-related macular degeneration (AMD). Design Population-based, cross-sectional analysis. Methods Serum homocysteine, vitamin B12, and folate were measured in 2,335 participants of the Blue Mountai...

Full description

Saved in:
Bibliographic Details
Published in:American journal of ophthalmology 2007-02, Vol.143 (2), p.344-346
Main Authors: Rochtchina, Elena, BSc, MApplStat, Wang, Jie Jin, MMed, PhD, Flood, Victoria M., MPH, PhD, Mitchell, Paul, MD, PhD
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biological and medical sciences
Confidence intervals
Cross-Sectional Studies
Female
Fluorescence Polarization Immunoassay
Folic Acid - blood
Homocysteine
Homocysteine - blood
Humans
Macular degeneration
Macular Degeneration - blood
Macular Degeneration - etiology
Male
Medical sciences
Middle Aged
Miscellaneous
New South Wales
Odds Ratio
Older people
Ophthalmology
Retinopathies
Risk Factors
Studies
Vitamin B 12 - blood
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose To assess associations between increased serum homocysteine, low vitamin B12, low folate, and age-related macular degeneration (AMD). Design Population-based, cross-sectional analysis. Methods Serum homocysteine, vitamin B12, and folate were measured in 2,335 participants of the Blue Mountains Eye Study second survey. AMD detected from retinal photographs included atrophic or neovascular lesions. Results After adjusting for age, gender, and smoking in logistic regression models, homocysteine >15 μmol/l was associated with an increased likelihood of AMD in participants aged
ISSN:0002-9394
1879-1891
DOI:10.1016/j.ajo.2006.08.032