Human papillomavirus-16 in oral squamous cell carcinoma: Clinical correlates and 5-year survival

Abstract We examined 66 oral squamous cell carcinomas (OSCCs) for human papillomavirus-16 (HPV-16) infection to evaluate its prognostic significance. Cox regression analysis of 5-year survival demonstrated that patients without nodal metastasis or with intratumoural HPV-16 showed better prognoses co...

Full description

Saved in:
Bibliographic Details
Published in:British journal of oral & maxillofacial surgery 2007-03, Vol.45 (2), p.116-122
Main Authors: Sugiyama, Masaru, Bhawal, Ujjal Kumar, Kawamura, Makoto, Ishioka, Yasuki, Shigeishi, Hideo, Higashikawa, Koichiro, Kamata, Nobuyuki
Format: Article
Language:English
Subjects:
5-year survival
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Carcinoma, Squamous Cell - mortality
Carcinoma, Squamous Cell - virology
Clinical correlates
Dentistry
Disease-Free Survival
DNA, Viral - analysis
Female
Human papillomavirus 16 - isolation & purification
Human papillomavirus-16
Humans
Kaplan-Meier Estimate
Logistic Models
Lymphatic Metastasis
Male
Medical sciences
Middle Aged
Mouth Neoplasms - mortality
Mouth Neoplasms - virology
Multivariate analysis
Oral squamous cell carcinoma
Otorhinolaryngology. Stomatology
Papillomavirus Infections - mortality
Proportional Hazards Models
Surgery
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract We examined 66 oral squamous cell carcinomas (OSCCs) for human papillomavirus-16 (HPV-16) infection to evaluate its prognostic significance. Cox regression analysis of 5-year survival demonstrated that patients without nodal metastasis or with intratumoural HPV-16 showed better prognoses compared with each counterpart. In Kaplan-Meier survival analysis, nodal status but not HPV-16 status was statistically significant. The 5-year survival rate of HPV-16 positive patients without nodal metastasis (94%) was extremely high, compared with that of HPV-16 negative patients with nodal metastasis (25%). These results suggest that HPV-16 status as well as nodal status may provide prognostic significance in patients with OSCC.
ISSN:0266-4356
1532-1940
DOI:10.1016/j.bjoms.2006.04.012