The immuno cross-reactivity of gutta percha points

Abstract Objective The purpose of this study is to test the postulated immuno cross-reactivity between proteins derived from raw gutta percha (RGP), gutta percha point (GPP) and natural rubber latex (NRL). Methods Antigenicity and cross-reactivity of proteins were determined by the FITkit (FITBiotec...

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Bibliographic Details
Published in:Dental materials 2007-03, Vol.23 (3), p.380-384
Main Authors: Kang, Peter B, Vogt, Kristy, Gruninger, Stephen E, Marshall, Milton, Siew, Chakwan, Meyer, Daniel M
Format: Article
Language:English
Subjects:
Advanced Basic Science
Biocompatibility
Cross Reactions
Dentistry
Enzyme-Linked Immunosorbent Assay
Gutta percha points
Gutta-Percha
Immuno cross-reactivity
Immunologic Tests
Latex
Latex Hypersensitivity - immunology
Mimusops
Natural rubber latex
Plant Proteins - immunology
Root Canal Filling Materials
Rubber
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Summary:Abstract Objective The purpose of this study is to test the postulated immuno cross-reactivity between proteins derived from raw gutta percha (RGP), gutta percha point (GPP) and natural rubber latex (NRL). Methods Antigenicity and cross-reactivity of proteins were determined by the FITkit (FITBiotech, Finland) and ELISA inhibition assays. Results Antigenicity of proteins derived from RGP or GPP was not demonstrated. Except for NRL glove extracts, neither extracts from RGP or GPP were reactive in ELISA inhibition assay. Significance There is no immunologic cross-reactivity in vitro between proteins derived from RGP or GPP, and from NRL gloves. Thus, therapeutic use of GPP is unlikely to initiate adverse immuno-reactivity in individuals previously sensitized to NRL proteins.
ISSN:0109-5641
1879-0097
DOI:10.1016/j.dental.2006.02.006