Cyclic AMP-dependent memory mutants are defective in the food choice behavior of Drosophila

Acute choice behavior in ingesting two different concentrations of sucrose in Drosophila is presumed to include learning and memory. Effects on this behavior were examined for four mutations that block associative learning (dunce, rutabaga, amnesiac, and radish). Three of these mutations cause cycli...

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Bibliographic Details
Published in:Journal of Comparative Physiology 2007-02, Vol.193 (2), p.279-283
Main Authors: Motosaka, Katsunori, Koganezawa, Masayuki, Narikawa, Satoko, Furuyama, Akira, Shinozaki, Kenji, Isono, Kunio, Shimada, Ichiro
Format: Article
Language:English
Subjects:
Adenylyl Cyclases - genetics
Adenylyl Cyclases - metabolism
Analysis of Variance
Animals
Choice Behavior - physiology
Cyclic AMP - genetics
Cyclic AMP - metabolism
Discrimination Learning - physiology
Drosophila melanogaster - genetics
Drosophila melanogaster - metabolism
Drosophila Proteins - genetics
Drosophila Proteins - metabolism
Feeding Behavior - physiology
Food Preferences - physiology
Insects
Memory - physiology
Mutation
Neuropeptides - genetics
Neuropeptides - metabolism
Phosphoproteins - genetics
Phosphoproteins - metabolism
Second Messenger Systems - genetics
Second Messenger Systems - physiology
Signal Transduction - genetics
Signal Transduction - physiology
Statistics, Nonparametric
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Summary:Acute choice behavior in ingesting two different concentrations of sucrose in Drosophila is presumed to include learning and memory. Effects on this behavior were examined for four mutations that block associative learning (dunce, rutabaga, amnesiac, and radish). Three of these mutations cause cyclic AMP signaling defects and significantly reduced taste discrimination. The exception was radish, which affects neither. Electrophysiological recordings confirmed that the sensitivity of taste receptors is almost indistinguishable in all flies, whether wild type or mutant. These results suggest that food choice behavior in Drosophila involves central nervous learning and memory operating via cyclic AMP signaling pathways.
ISSN:0340-7594
1432-1351
DOI:10.1007/s00359-006-0200-z