Postinfarct cortical plasticity and behavioral recovery

Plasticity phenomena in the cerebral cortex after ischemic injury have been documented repeatedly over the past 2 decades both in animal models and in human stroke survivors. This review highlights many of the major neuroanatomic and neurophysiological changes that characterize poststroke plasticity...

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Bibliographic Details
Published in:Stroke (1970) 2007-02, Vol.38 (2), p.840-845
Main Author: NUDO, Randolph J
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Brain - pathology
Brain - physiology
Brain - physiopathology
Cerebral Infarction - pathology
Cerebral Infarction - physiopathology
Cerebral Infarction - rehabilitation
Humans
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Nervous system
Nervous system (semeiology, syndromes)
Nervous system as a whole
Neurology
Neuronal Plasticity - physiology
Radionuclide investigations
Recovery of Function - physiology
Time Factors
Vascular diseases and vascular malformations of the nervous system
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Summary:Plasticity phenomena in the cerebral cortex after ischemic injury have been documented repeatedly over the past 2 decades both in animal models and in human stroke survivors. This review highlights many of the major neuroanatomic and neurophysiological changes that characterize poststroke plasticity in experimental animals. Spared regions adjacent to the infarct and far removed from the infarct undergo functional alterations that are modified by behavioral experience. Recent evidence is also reviewed, demonstrating that long-range intracortical pathways can be rerouted to completely novel territories. The implications of this new finding for understanding the brain's capacity for recovery are discussed.
ISSN:0039-2499
1524-4628
DOI:10.1161/01.str.0000247943.12887.d2