Primary large cell neuroendocrine carcinoma of the urinary bladder

Primary large cell neuroendocrine carcinomas (LCNEC) of the urinary bladder are rare. Reported herein is a case of a primary, pure LCNEC occurring in a man. The patient was a 32‐year‐old man who presented with hematuria of 1 week's duration. On cystoscopic examination, a solitary mass measuring...

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Bibliographic Details
Published in:Pathology international 2006-11, Vol.56 (11), p.688-693
Main Authors: Lee, Kyung Hwa, Ryu, Soo Bang, Lee, Min Cheol, Park, Chang Soo, Juhng, Sang Woo, Choi, Chan
Format: Article
Language:English
Subjects:
Adult
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Biomarkers, Tumor - metabolism
Carcinoma, Large Cell - secondary
Carcinoma, Large Cell - surgery
Carcinoma, Large Cell - therapy
Carcinoma, Neuroendocrine - secondary
Carcinoma, Neuroendocrine - surgery
Carcinoma, Neuroendocrine - therapy
Chemotherapy, Adjuvant
chromogranin A
Combined Modality Therapy
Cystectomy
Hospice Care
Humans
Immunoenzyme Techniques
large cell neuroendocrine carcinoma
Male
Neoplasm Recurrence, Local
synaptophysin
urinary bladder
Urinary Bladder Neoplasms - pathology
Urinary Bladder Neoplasms - surgery
Urinary Bladder Neoplasms - therapy
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Summary:Primary large cell neuroendocrine carcinomas (LCNEC) of the urinary bladder are rare. Reported herein is a case of a primary, pure LCNEC occurring in a man. The patient was a 32‐year‐old man who presented with hematuria of 1 week's duration. On cystoscopic examination, a solitary mass measuring 3 cm in diameter was detected protruding from the anterosuperior wall of the urinary bladder. Two months after the primary transurethral resection, significant regrowth of the remnant mass was noted on CT, and the patient underwent a partial cystectomy. A diagnosis of LCNEC was made based upon histological and immunohistochemical findings. Tumor cells were positive for synaptophysin, chromogranin A, CD56, epithelial membrane antigen, and cytokeratin. Histologically, the tumor penetrated the deep muscle and perivesical fat. In spite of three cycles of chemotherapy, the patient developed multiple metastases in the lung and liver 10 months postoperatively. LCNEC of the urinary bladder are uncommon entities, which have a possible fatal outcome.
ISSN:1320-5463
1440-1827
DOI:10.1111/j.1440-1827.2006.02031.x