Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

Many lines of evidence suggest that mitochondria have a central role in ageing-related neurodegenerative diseases. Mitochondria are critical regulators of cell death, a key feature of neurodegeneration. Mutations in mitochondrial DNA and oxidative stress both contribute to ageing, which is the great...

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Bibliographic Details
Published in:Nature 2006-10, Vol.443 (7113), p.787-795
Main Authors: Beal, M. Flint, Lin, Michael T
Format: Article
Language:English
Subjects:
Aging
Animals
Apoptosis
Humanities and Social Sciences
Humans
Mitochondria - genetics
Mitochondria - metabolism
Mitochondria - pathology
Mitochondrial DNA
multidisciplinary
Mutation
Neurodegenerative Diseases - genetics
Neurodegenerative Diseases - metabolism
Neurodegenerative Diseases - pathology
Neurological disorders
Oxidation
Oxidative Stress
Proteins
review-article
Risk factors
Science
Science (multidisciplinary)
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Summary:Many lines of evidence suggest that mitochondria have a central role in ageing-related neurodegenerative diseases. Mitochondria are critical regulators of cell death, a key feature of neurodegeneration. Mutations in mitochondrial DNA and oxidative stress both contribute to ageing, which is the greatest risk factor for neurodegenerative diseases. In all major examples of these diseases there is strong evidence that mitochondrial dysfunction occurs early and acts causally in disease pathogenesis. Moreover, an impressive number of disease-specific proteins interact with mitochondria. Thus, therapies targeting basic mitochondrial processes, such as energy metabolism or free-radical generation, or specific interactions of disease-related proteins with mitochondria, hold great promise.
ISSN:0028-0836
1476-4687
1476-4679
DOI:10.1038/nature05292