Complementary suppression of T cell activation by peritoneal macrophages and CTLA-4-Ig

Abstract Peritoneal macrophages suppressed T lymphocyte activation by amino acid catabolism. CTLA-4-Ig complemented this form of suppression by blocking the costimulation of T cells. Inhibition of the amino acid catabolizing enzymes or blockade of the IFN γ signaling essential for macrophage-mediate...

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Bibliographic Details
Published in:Immunobiology (1979) 2007-01, Vol.212 (1), p.1-10
Main Authors: Yeh, Kenny, Silberman, Daniel, Gonzalez, Diana, Riggs, James
Format: Article
Language:English
Subjects:
Abatacept
Advanced Basic Science
Allergy and Immunology
Animals
APC
CD80/86
Costimulation
CTLA-4-Ig
Female
Flow Cytometry
Fluorescent Antibody Technique
IDO
Immunoconjugates - immunology
Immunoconjugates - metabolism
Indoleamine-Pyrrole 2,3,-Dioxygenase - immunology
Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism
iNOS
Interferon-gamma - immunology
Interferon-gamma - metabolism
Lymphocyte Activation - immunology
Lymphocyte Culture Test, Mixed
Macrophage
Macrophages, Peritoneal - immunology
Macrophages, Peritoneal - metabolism
Mice
Mice, SCID
Nitric Oxide Synthase Type II - immunology
Nitric Oxide Synthase Type II - metabolism
T-Lymphocytes - immunology
T-Lymphocytes - metabolism
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Description
Summary:Abstract Peritoneal macrophages suppressed T lymphocyte activation by amino acid catabolism. CTLA-4-Ig complemented this form of suppression by blocking the costimulation of T cells. Inhibition of the amino acid catabolizing enzymes or blockade of the IFN γ signaling essential for macrophage-mediated suppression did not impact CTLA-4-Ig efficacy. Except for phytohemagglutinin, T cell responses to superantigen, mitogen, and anti-CD3 were further reduced when CTLA-4-Ig was combined with peritoneal macrophages. The combination of these complimentary forms of immune regulation potently suppresses adaptive immunity.
ISSN:0171-2985
1878-3279
DOI:10.1016/j.imbio.2006.05.026