Formation of self-organized nanoparticles by lecithin/chitosan ionic interaction

In this work the production of auto-assembled nanoparticles obtained by the mixing of chitosan and lecithin is presented. The size and surface charge of the nanoparticles were studied as function of the weight ratio between components, the viscosity of the polysaccharide and the pH of the colloidal...

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Bibliographic Details
Published in:International journal of pharmaceutics 2006-10, Vol.324 (1), p.67-73
Main Authors: Sonvico, F., Cagnani, A., Rossi, A., Motta, S., Di Bari, M.T., Cavatorta, F., Alonso, M.J., Deriu, A., Colombo, P.
Format: Article
Language:English
Subjects:
Algorithms
Biological and medical sciences
Chemical Phenomena
Chemistry, Physical
Chitosan
Chitosan - chemistry
Drug Compounding
Electrochemistry
General pharmacology
Hydrogen-Ion Concentration
Lecithin
Lipids - chemistry
Medical sciences
Microscopy, Atomic Force
Microscopy, Electron, Transmission
Nanoparticles
Neutrons
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Phosphatidylcholines - chemistry
Progesterone - administration & dosage
Progesterone - chemistry
Scattering, Radiation
Self-organizing structures
Solubility
Spectroscopy, Fourier Transform Infrared
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Summary:In this work the production of auto-assembled nanoparticles obtained by the mixing of chitosan and lecithin is presented. The size and surface charge of the nanoparticles were studied as function of the weight ratio between components, the viscosity of the polysaccharide and the pH of the colloidal suspension. In order to elucidate the structure of nanoparticles, micro-FT-IR and elastic neutron scattering experiments have been performed. Results evidenced a strong electrostatic interaction between components and a structure that is neither that of homogeneous spheres nor of coated unilamellar vesicles. Preliminary encapsulation experiments with progesterone, as model lipophilic drug, showed good encapsulation efficiencies.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2006.06.036