Endophthalmitis After Open Globe Injury: Microbiologic Spectrum and Susceptibilities of Isolates

To present the microbiologic spectrum and susceptibilities of isolates in posttraumatic endophthalmitis, and to provide a review of the literature. Retrospective consecutive case series. A review of 1182 consecutive open globe injuries was performed, identifying 10 patients with culture-proven endop...

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Bibliographic Details
Published in:American journal of ophthalmology 2006-11, Vol.142 (5), p.852-854
Main Authors: Chhabra, Sachin, Kunimoto, Derek Y., Kazi, Lubna, Regillo, Carl D., Ho, Allen C., Belmont, Jonathan, Maguire, Joseph, Vander, James, Brown, Gary C.
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Aqueous Humor - microbiology
Bacteria
Bacteria - drug effects
Bacteria - isolation & purification
Bacteriology
Biological and medical sciences
Drug Resistance, Bacterial
Endophthalmitis - microbiology
Eye Infections, Bacterial - microbiology
Eye Injuries, Penetrating - microbiology
Fungi
Gram-negative bacteria
Humans
Infections
Medical sciences
Microbial Sensitivity Tests
Microorganisms
Miscellaneous
Ophthalmology
Retrospective Studies
Vitreous Body - microbiology
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Summary:To present the microbiologic spectrum and susceptibilities of isolates in posttraumatic endophthalmitis, and to provide a review of the literature. Retrospective consecutive case series. A review of 1182 consecutive open globe injuries was performed, identifying 10 patients with culture-proven endophthalmitis. Thirteen organisms were isolated from 10 eyes with posttraumatic endophthalmitis. Isolated organisms included Streptococcus species (46.2%), coagulase-negative Staphylococcus (23.1%), and Bacillus cereus (15.4%). All organisms tested were susceptible to vancomycin and tobramycin. The most commonly isolated organisms from an aggregate posttraumatic endophthalmitis pool of 372 cases obtained by literature-based meta-analysis were coagulase-negative Staphylococcus (21.5%) and Bacillus cereus (18.5%). We report a high prevalence of gram-positive pathogens and a notable prevalence of Bacillus cereus in posttraumatic endophthalmitis. Susceptibility results suggest that posttraumatic endophthalmitis isolates are generally susceptible to vancomycin and tobramycin.
ISSN:0002-9394
1879-1891
DOI:10.1016/j.ajo.2006.05.024