Neonatal Subependymal Giant Cell Astrocytoma: New Case and Review of Literature

Subependymal giant cell astrocytomas are one of the three major intracranial lesions found in tuberous sclerosis complex. Subependymal giant cell astrocytomas are typically slow-growing tumors of mixed glioneuronal lineage which can become aggressive and cause obstructive hydrocephalus usually in ol...

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Bibliographic Details
Published in:Pediatric neurology 2007-02, Vol.36 (2), p.128-131
Main Authors: Raju, G. Praveen, MD, PhD, Urion, David K., MD, Sahin, Mustafa, MD, PhD
Format: Article
Language:English
Subjects:
Adult
Astrocytoma - congenital
Astrocytoma - pathology
Biological and medical sciences
Brain Neoplasms - congenital
Brain Neoplasms - pathology
Development. Senescence. Regeneration. Transplantation
Fatal Outcome
Female
Fundamental and applied biological sciences. Psychology
Humans
Infant, Newborn
Magnetic Resonance Imaging
Medical sciences
Neurology
Pediatrics
Pregnancy
Pregnancy, High-Risk
Prenatal Diagnosis
Tuberous Sclerosis
Tumors of the nervous system. Phacomatoses
Vertebrates: nervous system and sense organs
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Summary:Subependymal giant cell astrocytomas are one of the three major intracranial lesions found in tuberous sclerosis complex. Subependymal giant cell astrocytomas are typically slow-growing tumors of mixed glioneuronal lineage which can become aggressive and cause obstructive hydrocephalus usually in older children and adolescents. Neonatal subependymal giant cell astrocytomas are extremely rare, and their natural history and prognosis are poorly understood. This report investigates an extremely large neonatal subependymal giant cell astrocytoma which was initially identified in utero at 19 weeks of gestation in a high-risk pregnancy with no family history of tuberous sclerosis complex.
ISSN:0887-8994
1873-5150
DOI:10.1016/j.pediatrneurol.2006.08.009