Clinical relevance of laboratory-reported antibiotic resistance in acute uncomplicated urinary tract infection in primary care

• Published in: Journal of antimicrobial chemotherapy 2006-11, Vol.58 (5), p.1000-1008
• Main Authors: McNulty, C. A. M., Richards, J., Livermore, D. M., Little, P., Charlett, A., Freeman, E., Harvey, I., Thomas, M.
• Format: Article
• Language: English
• Subjects: Acute Disease; Adult; Aged; Anti-Infective Agents - pharmacology; Anti-Infective Agents - therapeutic use; Antibiotics; Antibiotics. Antiinfectious agents. Antiparasitic agents; Bacterial diseases; Bacterial diseases of the urinary system; Biological and medical sciences; Chemotherapy; clinical outcome; Clinical outcomes; cohort; Cohort Studies; Community-Acquired Infections - drug therapy; Community-Acquired Infections - microbiology; community/primary care; Drug resistance; Epidemiology; Female; Human bacterial diseases; Humans; Infectious diseases; Medical sciences; Microbial Sensitivity Tests; Middle Aged; Nephrology. Urinary tract diseases; Pharmacology. Drug treatments; Primary care; Primary Health Care; Prospective Studies; Treatment Outcome; trimethoprim; Trimethoprim - pharmacology; Trimethoprim - therapeutic use; Trimethoprim Resistance; Urinary system involvement in other diseases. Miscellaneous; Urinary tract diseases; Urinary Tract Infections - drug therapy; Urinary Tract Infections - microbiology; Urinary tract. Prostate gland; UTI
• ISSN: 0305-7453; 1460-2091
• DOI: 10.1093/jac/dkl368

Objectives: To determine whether patients with an uncomplicated community-acquired urinary tract infection (UTI) and an isolate resistant to trimethoprim had worse clinical outcomes following empirical treatment with trimethoprim 200 mg twice daily for 3 days than did those with a susceptible isolate. Patients and methods: This was a prospective cohort study of clinical outcome. We enrolled 497 women (≥18–70 years) presenting to general practitioner surgeries in Norwich and Gloucester with at least two symptoms of acute (