Immunity against Babesia rossi infection in dogs vaccinated with antigens from culture supernatants

Soluble parasite antigens (SPA) from different Babesia species have been shown earlier to induce protective immunity when used as vaccine. However, initial attempts to produce such vaccine against Babesia rossi infection using SPA from B. rossi culture supernatants were not or only partially success...

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Bibliographic Details
Published in:Veterinary parasitology 2007-03, Vol.144 (1), p.10-19
Main Authors: Schetters, Th.P.M., Strydom, T., Crafford, D., Kleuskens, J.A.G.M., van de Crommert, J., Vermeulen, A.N.
Format: Article
Language:English
Subjects:
Animals
Antibodies, Protozoan - biosynthesis
antigens
Antigens, Protozoan
Babesia
Babesia - immunology
Babesia canis
Babesia rossi
babesiosis
Babesiosis - immunology
Babesiosis - prevention & control
Babesiosis - veterinary
Canis
Dog Diseases - immunology
Dog Diseases - prevention & control
Dogs
Erythrocytes - parasitology
Female
Hematocrit - veterinary
Immunity
Immunization, Secondary - veterinary
Male
Nobivac ® Piro
parasitemia
Parasitemia - veterinary
protective effect
Protozoan Vaccines - immunology
Soluble parasite antigens
Time Factors
vaccination
Vaccine
vaccine development
vaccines
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Summary:Soluble parasite antigens (SPA) from different Babesia species have been shown earlier to induce protective immunity when used as vaccine. However, initial attempts to produce such vaccine against Babesia rossi infection using SPA from B. rossi culture supernatants were not or only partially successful. Here we show that when dogs were vaccinated with a vaccine comprising SPA from B. rossi combined with SPA from Babesia canis protective immunity against experimental challenge infection was induced. Immunity was reflected in reduced clinical signs that resolved spontaneously, and reduction of parasitaemia and SPA in the blood. Not a single infected erythrocyte could be found in blood smears of dogs that had been repeatedly boosted (three vaccinations in total). In contrast, three out of four control dogs required chemotherapeutic treatment to prevent death. The fourth control dog showed a transient parasitaemia that resolved spontaneously. Vaccination did not prevent the development of a transient anaemia. It is concluded that a vaccine containing a mixture of SPA obtained from in vitro culture supernatants of B. rossi and B. canis induces protection in dogs against heterologous challenge infection with B. canis (as shown before) or B. rossi.
ISSN:0304-4017
1873-2550
DOI:10.1016/j.vetpar.2006.09.026