The MLL partial tandem duplication in acute myeloid leukaemia

Summary Mixed lineage leukaemia gene‐partial tandem duplications (MLL‐PTD) characterise acute myeloid leukaemia (AML) with trisomy 11 and AML with a normal karyotype. MLL‐PTD confer a worse prognosis with shortened overall and event free survival in childhood and adult AML. In spite of these clinica...

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Bibliographic Details
Published in:British journal of haematology 2006-11, Vol.135 (4), p.438-449
Main Authors: Basecke, Jorg, Whelan, Jarrett T., Griesinger, Frank, Bertrand, Fred E.
Format: Article
Language:English
Subjects:
Acute Disease
acute myeloid leukaemia
Biological and medical sciences
Cell Transformation, Neoplastic - genetics
Chromosomes, Human, Pair 11 - genetics
DNA, Neoplasm - genetics
Gene Duplication
Genetic Predisposition to Disease
Hematologic and hematopoietic diseases
Histone-Lysine N-Methyltransferase
Humans
leukaemogenesis
Leukemia, Myeloid - genetics
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Medical sciences
MLL
Myeloid-Lymphoid Leukemia Protein - genetics
Prognosis
tandem duplication
Tandem Repeat Sequences
Trisomy
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Summary:Summary Mixed lineage leukaemia gene‐partial tandem duplications (MLL‐PTD) characterise acute myeloid leukaemia (AML) with trisomy 11 and AML with a normal karyotype. MLL‐PTD confer a worse prognosis with shortened overall and event free survival in childhood and adult AML. In spite of these clinical observations, the leukaemogenic mechanism has, so far, not been determined. This review summarises clinical studies on MLL‐PTD positive AML and recent experimental findings on the putative leukaemogenic role of MLL‐PTD.
ISSN:0007-1048
1365-2141
DOI:10.1111/j.1365-2141.2006.06301.x