Loading…
The MLL partial tandem duplication in acute myeloid leukaemia
Summary Mixed lineage leukaemia gene‐partial tandem duplications (MLL‐PTD) characterise acute myeloid leukaemia (AML) with trisomy 11 and AML with a normal karyotype. MLL‐PTD confer a worse prognosis with shortened overall and event free survival in childhood and adult AML. In spite of these clinica...
Saved in:
| Published in: | British journal of haematology 2006-11, Vol.135 (4), p.438-449 |
|---|---|
| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c3971-97e0e672ece02072d248c808d1761b8065b91ebf42155d33af294c821d0fd55f3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c3971-97e0e672ece02072d248c808d1761b8065b91ebf42155d33af294c821d0fd55f3 |
| container_end_page | 449 |
| container_issue | 4 |
| container_start_page | 438 |
| container_title | British journal of haematology |
| container_volume | 135 |
| creator | Basecke, Jorg Whelan, Jarrett T. Griesinger, Frank Bertrand, Fred E. |
| description | Summary
Mixed lineage leukaemia gene‐partial tandem duplications (MLL‐PTD) characterise acute myeloid leukaemia (AML) with trisomy 11 and AML with a normal karyotype. MLL‐PTD confer a worse prognosis with shortened overall and event free survival in childhood and adult AML. In spite of these clinical observations, the leukaemogenic mechanism has, so far, not been determined. This review summarises clinical studies on MLL‐PTD positive AML and recent experimental findings on the putative leukaemogenic role of MLL‐PTD. |
| doi_str_mv | 10.1111/j.1365-2141.2006.06301.x |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68987246</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68987246</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3971-97e0e672ece02072d248c808d1761b8065b91ebf42155d33af294c821d0fd55f3</originalsourceid><addsrcrecordid>eNqNkE1v1DAQQC0EotvCX0C-wC1hxo4d59ADVECLFnEpZ8trT4QXJ1niRO3-exJ2Ra_MZUaaNx96jHGEEpd4vy9RalUIrLAUALoELQHLx2ds86_xnG0AoC4QKnPBLnPeA6AEhS_ZBepGK2nUhl3f_yT-bbvlBzdO0SU-uT5Qx8N8SNG7KQ49jz13fp6Id0dKQww80fzLURfdK_aidSnT63O-Yj8-f7q_uS2237_c3XzYFl42NRZNTUC6FuQJBNQiiMp4AyZgrXFnQKtdg7RrK4FKBSldK5rKG4EB2qBUK6_Yu9Pewzj8nilPtovZU0qup2HOVpvG1KLSC2hOoB-HnEdq7WGMnRuPFsGu6uzerobsasiu6uxfdfZxGX1zvjHvOgpPg2dXC_D2DLjsXWpH1_uYnzgjKiVls3DXJ-4hJjr-9wP249fbtZJ_ADuNh6w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68987246</pqid></control><display><type>article</type><title>The MLL partial tandem duplication in acute myeloid leukaemia</title><source>Wiley</source><creator>Basecke, Jorg ; Whelan, Jarrett T. ; Griesinger, Frank ; Bertrand, Fred E.</creator><creatorcontrib>Basecke, Jorg ; Whelan, Jarrett T. ; Griesinger, Frank ; Bertrand, Fred E.</creatorcontrib><description>Summary
Mixed lineage leukaemia gene‐partial tandem duplications (MLL‐PTD) characterise acute myeloid leukaemia (AML) with trisomy 11 and AML with a normal karyotype. MLL‐PTD confer a worse prognosis with shortened overall and event free survival in childhood and adult AML. In spite of these clinical observations, the leukaemogenic mechanism has, so far, not been determined. This review summarises clinical studies on MLL‐PTD positive AML and recent experimental findings on the putative leukaemogenic role of MLL‐PTD.</description><identifier>ISSN: 0007-1048</identifier><identifier>EISSN: 1365-2141</identifier><identifier>DOI: 10.1111/j.1365-2141.2006.06301.x</identifier><identifier>PMID: 16965385</identifier><identifier>CODEN: BJHEAL</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Acute Disease ; acute myeloid leukaemia ; Biological and medical sciences ; Cell Transformation, Neoplastic - genetics ; Chromosomes, Human, Pair 11 - genetics ; DNA, Neoplasm - genetics ; Gene Duplication ; Genetic Predisposition to Disease ; Hematologic and hematopoietic diseases ; Histone-Lysine N-Methyltransferase ; Humans ; leukaemogenesis ; Leukemia, Myeloid - genetics ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Medical sciences ; MLL ; Myeloid-Lymphoid Leukemia Protein - genetics ; Prognosis ; tandem duplication ; Tandem Repeat Sequences ; Trisomy</subject><ispartof>British journal of haematology, 2006-11, Vol.135 (4), p.438-449</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3971-97e0e672ece02072d248c808d1761b8065b91ebf42155d33af294c821d0fd55f3</citedby><cites>FETCH-LOGICAL-c3971-97e0e672ece02072d248c808d1761b8065b91ebf42155d33af294c821d0fd55f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18245339$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16965385$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Basecke, Jorg</creatorcontrib><creatorcontrib>Whelan, Jarrett T.</creatorcontrib><creatorcontrib>Griesinger, Frank</creatorcontrib><creatorcontrib>Bertrand, Fred E.</creatorcontrib><title>The MLL partial tandem duplication in acute myeloid leukaemia</title><title>British journal of haematology</title><addtitle>Br J Haematol</addtitle><description>Summary
Mixed lineage leukaemia gene‐partial tandem duplications (MLL‐PTD) characterise acute myeloid leukaemia (AML) with trisomy 11 and AML with a normal karyotype. MLL‐PTD confer a worse prognosis with shortened overall and event free survival in childhood and adult AML. In spite of these clinical observations, the leukaemogenic mechanism has, so far, not been determined. This review summarises clinical studies on MLL‐PTD positive AML and recent experimental findings on the putative leukaemogenic role of MLL‐PTD.</description><subject>Acute Disease</subject><subject>acute myeloid leukaemia</subject><subject>Biological and medical sciences</subject><subject>Cell Transformation, Neoplastic - genetics</subject><subject>Chromosomes, Human, Pair 11 - genetics</subject><subject>DNA, Neoplasm - genetics</subject><subject>Gene Duplication</subject><subject>Genetic Predisposition to Disease</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Histone-Lysine N-Methyltransferase</subject><subject>Humans</subject><subject>leukaemogenesis</subject><subject>Leukemia, Myeloid - genetics</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Medical sciences</subject><subject>MLL</subject><subject>Myeloid-Lymphoid Leukemia Protein - genetics</subject><subject>Prognosis</subject><subject>tandem duplication</subject><subject>Tandem Repeat Sequences</subject><subject>Trisomy</subject><issn>0007-1048</issn><issn>1365-2141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNqNkE1v1DAQQC0EotvCX0C-wC1hxo4d59ADVECLFnEpZ8trT4QXJ1niRO3-exJ2Ra_MZUaaNx96jHGEEpd4vy9RalUIrLAUALoELQHLx2ds86_xnG0AoC4QKnPBLnPeA6AEhS_ZBepGK2nUhl3f_yT-bbvlBzdO0SU-uT5Qx8N8SNG7KQ49jz13fp6Id0dKQww80fzLURfdK_aidSnT63O-Yj8-f7q_uS2237_c3XzYFl42NRZNTUC6FuQJBNQiiMp4AyZgrXFnQKtdg7RrK4FKBSldK5rKG4EB2qBUK6_Yu9Pewzj8nilPtovZU0qup2HOVpvG1KLSC2hOoB-HnEdq7WGMnRuPFsGu6uzerobsasiu6uxfdfZxGX1zvjHvOgpPg2dXC_D2DLjsXWpH1_uYnzgjKiVls3DXJ-4hJjr-9wP249fbtZJ_ADuNh6w</recordid><startdate>200611</startdate><enddate>200611</enddate><creator>Basecke, Jorg</creator><creator>Whelan, Jarrett T.</creator><creator>Griesinger, Frank</creator><creator>Bertrand, Fred E.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200611</creationdate><title>The MLL partial tandem duplication in acute myeloid leukaemia</title><author>Basecke, Jorg ; Whelan, Jarrett T. ; Griesinger, Frank ; Bertrand, Fred E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3971-97e0e672ece02072d248c808d1761b8065b91ebf42155d33af294c821d0fd55f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Acute Disease</topic><topic>acute myeloid leukaemia</topic><topic>Biological and medical sciences</topic><topic>Cell Transformation, Neoplastic - genetics</topic><topic>Chromosomes, Human, Pair 11 - genetics</topic><topic>DNA, Neoplasm - genetics</topic><topic>Gene Duplication</topic><topic>Genetic Predisposition to Disease</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Histone-Lysine N-Methyltransferase</topic><topic>Humans</topic><topic>leukaemogenesis</topic><topic>Leukemia, Myeloid - genetics</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Medical sciences</topic><topic>MLL</topic><topic>Myeloid-Lymphoid Leukemia Protein - genetics</topic><topic>Prognosis</topic><topic>tandem duplication</topic><topic>Tandem Repeat Sequences</topic><topic>Trisomy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Basecke, Jorg</creatorcontrib><creatorcontrib>Whelan, Jarrett T.</creatorcontrib><creatorcontrib>Griesinger, Frank</creatorcontrib><creatorcontrib>Bertrand, Fred E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Basecke, Jorg</au><au>Whelan, Jarrett T.</au><au>Griesinger, Frank</au><au>Bertrand, Fred E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The MLL partial tandem duplication in acute myeloid leukaemia</atitle><jtitle>British journal of haematology</jtitle><addtitle>Br J Haematol</addtitle><date>2006-11</date><risdate>2006</risdate><volume>135</volume><issue>4</issue><spage>438</spage><epage>449</epage><pages>438-449</pages><issn>0007-1048</issn><eissn>1365-2141</eissn><coden>BJHEAL</coden><abstract>Summary
Mixed lineage leukaemia gene‐partial tandem duplications (MLL‐PTD) characterise acute myeloid leukaemia (AML) with trisomy 11 and AML with a normal karyotype. MLL‐PTD confer a worse prognosis with shortened overall and event free survival in childhood and adult AML. In spite of these clinical observations, the leukaemogenic mechanism has, so far, not been determined. This review summarises clinical studies on MLL‐PTD positive AML and recent experimental findings on the putative leukaemogenic role of MLL‐PTD.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>16965385</pmid><doi>10.1111/j.1365-2141.2006.06301.x</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-1048 |
| ispartof | British journal of haematology, 2006-11, Vol.135 (4), p.438-449 |
| issn | 0007-1048 1365-2141 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68987246 |
| source | Wiley |
| subjects | Acute Disease acute myeloid leukaemia Biological and medical sciences Cell Transformation, Neoplastic - genetics Chromosomes, Human, Pair 11 - genetics DNA, Neoplasm - genetics Gene Duplication Genetic Predisposition to Disease Hematologic and hematopoietic diseases Histone-Lysine N-Methyltransferase Humans leukaemogenesis Leukemia, Myeloid - genetics Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences MLL Myeloid-Lymphoid Leukemia Protein - genetics Prognosis tandem duplication Tandem Repeat Sequences Trisomy |
| title | The MLL partial tandem duplication in acute myeloid leukaemia |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T22%3A11%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20MLL%20partial%20tandem%20duplication%20in%20acute%20myeloid%20leukaemia&rft.jtitle=British%20journal%20of%20haematology&rft.au=Basecke,%20Jorg&rft.date=2006-11&rft.volume=135&rft.issue=4&rft.spage=438&rft.epage=449&rft.pages=438-449&rft.issn=0007-1048&rft.eissn=1365-2141&rft.coden=BJHEAL&rft_id=info:doi/10.1111/j.1365-2141.2006.06301.x&rft_dat=%3Cproquest_cross%3E68987246%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c3971-97e0e672ece02072d248c808d1761b8065b91ebf42155d33af294c821d0fd55f3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=68987246&rft_id=info:pmid/16965385&rfr_iscdi=true |