Body Mass Index and Physical Activity as Risk Factors for Pancreatic Cancer: The Multiethnic Cohort Study

Objective To examine body mass index (BMI) and physical activity as risk factors for pancreatic cancer. Methods Eight-year prospective data from 77,255 men and 90,175 women including 237 and 235 pancreatic cancer cases, respectively, in the Hawaii-Los Angeles Multiethnic Cohort Study were analyzed....

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Bibliographic Details
Published in:Cancer causes & control 2007-03, Vol.18 (2), p.165-175
Main Authors: Nöthlings, Ute, Wilkens, Lynne R., Murphy, Suzanne P., Hankin, Jean H., Henderson, Brian E., Kolonel, Laurence N.
Format: Article
Language:English
Subjects:
African Americans
Aged
Asian Americans
Body Mass Index
Cohort Studies
Diabetes mellitus
European Continental Ancestry Group
Exercise
Female
Hawaii - epidemiology
Hawaii - ethnology
Hispanic Americans
Humans
Los Angeles - epidemiology
Male
Men
Middle Aged
Motor Activity
Obesity
Overweight
Pancreatic cancer
Pancreatic neoplasms
Pancreatic Neoplasms - epidemiology
Predisposing factors
Proportional Hazards Models
Prospective Studies
Registries - statistics & numerical data
Risk
Sex Factors
Tobacco smoking
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Summary:Objective To examine body mass index (BMI) and physical activity as risk factors for pancreatic cancer. Methods Eight-year prospective data from 77,255 men and 90,175 women including 237 and 235 pancreatic cancer cases, respectively, in the Hawaii-Los Angeles Multiethnic Cohort Study were analyzed. Participants completed a questionnaire that included questions on body weight, height, and physical activity. Cox proportional hazards models were calculated to estimate relative risks (RR) of pancreatic cancer by levels of BMI and total physical activity (as metabolic equivalents (METs)) adjusted for several potential confounders. Results Obesity (BMI ≥ 30 kg/m²) was associated with an increased pancreatic cancer risk in men (RR = 1.51 (95% CI: 1.02-2.26)), but a reduced risk in women (RR = 0.65 (95% CI: 0.43-0.99)). In men the risk was higher in never smokers than in current or former smokers, though differences were not statistically significant. Physical activity was not associated with pancreatic cancer risk in either men or women. Conclusion The findings suggest, that a BMI of ≥ 30 kg/m² may be a risk factor for pancreatic cancer in men. No evidence of an effect of physical activity on risk was found.
ISSN:0957-5243
1573-7225
DOI:10.1007/s10552-006-0100-0