Copper(II) complexes of tridentate N, N, N′, N″, N″-pentamethyldiethylenetriamine: Superoxide dismutase and inhibitory activity against bacteria and fungi

• Published in: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Molecular and biomolecular spectroscopy, 2007-03, Vol.66 (3), p.726-731
• Main Authors: Patel, R.N., Singh, Nripendra, Gundla, V.L.N., Chauhan, U.K.
• Format: Article
• Language: English
• Subjects: Anti-microbial activity; Bacteria - drug effects; Copper - chemistry; Copper - pharmacology; Copper(II) complexes; Crystal structure; Crystallography, X-Ray; Electron paramagnetic resonance (e.p.r.); Electron Spin Resonance Spectroscopy; Fungi - drug effects; Humans; Magnetics; Microbial Sensitivity Tests; Organometallic Compounds - pharmacology; Polyamines - chemistry; Polyamines - pharmacology; Spectrophotometry, Ultraviolet; Superoxide dismutase (SOD); Superoxide Dismutase - metabolism
• ISSN: 1386-1425
• DOI: 10.1016/j.saa.2006.04.017

A series of ternary copper(II) complexes containing same coordination sphere but difference in the counter ions, viz., [Cu(PMDT)(OAc)]PF 6 (1); [Cu(PMDT)(OAc)]ClO 4 (2); [Cu(PMDT)(OAc)]BF 4 (3) and [Cu(PMDT)(OAc)]BPh 4 (4) where PMDT = N, N, N′, N″, N″-pentamethyldiethylenetriamine, OAc = Acetate ion were synthesized and characterized by means of spectroscopic, magnetic and cyclic voltammetric measurements. In frozen solution e.p.r. spectra, an interesting relation g || > g ⊥ has been observed which is a typical of the axially symmetric d 9 Cu II ( S Cu = 1/2) having an unpaired electron in a d x 2 − y 2 orbital. Single crystal X-ray analysis of (1) has revealed the presence of distorted square planar geometry. The influence of the counter ion on the complexes has been examined by performing some biological experiments like superoxide dismutase and anti-microbial activity.