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Xanthophyll accumulation in the human retina during supplementation with lutein or zeaxanthin – the LUXEA (LUtein Xanthophyll Eye Accumulation) study
The xanthophylls lutein (L) and zeaxanthin (Z) form the macular pigment with the highest density in the macula lutea. We investigated Macular Pigment Optical Density (MPOD) responses to supplementation with identically formulated (Actilease™) L or Z (OPTISHARP™) or L + Z over 6–12 months using doses...
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Published in: | Archives of biochemistry and biophysics 2007-02, Vol.458 (2), p.128-135 |
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container_title | Archives of biochemistry and biophysics |
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creator | Schalch, Wolfgang Cohn, William Barker, Felix M. Köpcke, Wolfgang Mellerio, John Bird, Alan C. Robson, Anthony G. Fitzke, Fred F. van Kuijk, Frederik J.G.M. |
description | The xanthophylls lutein (L) and zeaxanthin (Z) form the macular pigment with the highest density in the
macula lutea. We investigated Macular Pigment Optical Density (MPOD) responses to supplementation with identically formulated (Actilease™) L or Z (OPTISHARP™) or L
+
Z over 6–12 months using doses of 10 or 20
mg/day. MPOD as well as blue light sensitivity in fovea and parafovea were measured monthly by heterochromatic flicker photometry. Average xanthophyll plasma concentrations, analysed monthly by HPLC, increased up to 27-fold. MPOD increased by 15% upon L or L
+
Z supplementation. Supplementation of Z alone produced similar pigment accumulation in fovea
and parafovea, which confounded MPOD measurements. After correction for this, a 14% MPOD increase resulted for Z. Thus, during supplementation with xanthophylls, L is predominantly deposited in the fovea while Z deposition appears to cover a wider retinal area. This may be relevant to health and disease of the retina. |
doi_str_mv | 10.1016/j.abb.2006.09.032 |
format | article |
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macula lutea. We investigated Macular Pigment Optical Density (MPOD) responses to supplementation with identically formulated (Actilease™) L or Z (OPTISHARP™) or L
+
Z over 6–12 months using doses of 10 or 20
mg/day. MPOD as well as blue light sensitivity in fovea and parafovea were measured monthly by heterochromatic flicker photometry. Average xanthophyll plasma concentrations, analysed monthly by HPLC, increased up to 27-fold. MPOD increased by 15% upon L or L
+
Z supplementation. Supplementation of Z alone produced similar pigment accumulation in fovea
and parafovea, which confounded MPOD measurements. After correction for this, a 14% MPOD increase resulted for Z. Thus, during supplementation with xanthophylls, L is predominantly deposited in the fovea while Z deposition appears to cover a wider retinal area. This may be relevant to health and disease of the retina.</description><identifier>ISSN: 0003-9861</identifier><identifier>EISSN: 1096-0384</identifier><identifier>DOI: 10.1016/j.abb.2006.09.032</identifier><identifier>PMID: 17084803</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; AMD ; Carotenoids ; Dietary Supplements ; Double-Blind Method ; Fovea ; Heterochromatic Flicker Photometry ; Humans ; Lutein ; Lutein - administration & dosage ; Lutein - blood ; Lutein - metabolism ; Macula Lutea - chemistry ; Macular pigment ; Male ; Middle Aged ; OPTISHARP ; Parafovea ; Pilot Projects ; Retina - metabolism ; Supplementation ; Xanthophylls - administration & dosage ; Xanthophylls - blood ; Xanthophylls - metabolism ; Zeaxanthin ; Zeaxanthins</subject><ispartof>Archives of biochemistry and biophysics, 2007-02, Vol.458 (2), p.128-135</ispartof><rights>2006 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c351t-5a39256401af76cd3caba393470a75e799c80bf311729b29a6f3c2ac6cc15cc63</citedby><cites>FETCH-LOGICAL-c351t-5a39256401af76cd3caba393470a75e799c80bf311729b29a6f3c2ac6cc15cc63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17084803$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schalch, Wolfgang</creatorcontrib><creatorcontrib>Cohn, William</creatorcontrib><creatorcontrib>Barker, Felix M.</creatorcontrib><creatorcontrib>Köpcke, Wolfgang</creatorcontrib><creatorcontrib>Mellerio, John</creatorcontrib><creatorcontrib>Bird, Alan C.</creatorcontrib><creatorcontrib>Robson, Anthony G.</creatorcontrib><creatorcontrib>Fitzke, Fred F.</creatorcontrib><creatorcontrib>van Kuijk, Frederik J.G.M.</creatorcontrib><title>Xanthophyll accumulation in the human retina during supplementation with lutein or zeaxanthin – the LUXEA (LUtein Xanthophyll Eye Accumulation) study</title><title>Archives of biochemistry and biophysics</title><addtitle>Arch Biochem Biophys</addtitle><description>The xanthophylls lutein (L) and zeaxanthin (Z) form the macular pigment with the highest density in the
macula lutea. We investigated Macular Pigment Optical Density (MPOD) responses to supplementation with identically formulated (Actilease™) L or Z (OPTISHARP™) or L
+
Z over 6–12 months using doses of 10 or 20
mg/day. MPOD as well as blue light sensitivity in fovea and parafovea were measured monthly by heterochromatic flicker photometry. Average xanthophyll plasma concentrations, analysed monthly by HPLC, increased up to 27-fold. MPOD increased by 15% upon L or L
+
Z supplementation. Supplementation of Z alone produced similar pigment accumulation in fovea
and parafovea, which confounded MPOD measurements. After correction for this, a 14% MPOD increase resulted for Z. Thus, during supplementation with xanthophylls, L is predominantly deposited in the fovea while Z deposition appears to cover a wider retinal area. This may be relevant to health and disease of the retina.</description><subject>Adolescent</subject><subject>Adult</subject><subject>AMD</subject><subject>Carotenoids</subject><subject>Dietary Supplements</subject><subject>Double-Blind Method</subject><subject>Fovea</subject><subject>Heterochromatic Flicker Photometry</subject><subject>Humans</subject><subject>Lutein</subject><subject>Lutein - administration & dosage</subject><subject>Lutein - blood</subject><subject>Lutein - metabolism</subject><subject>Macula Lutea - chemistry</subject><subject>Macular pigment</subject><subject>Male</subject><subject>Middle Aged</subject><subject>OPTISHARP</subject><subject>Parafovea</subject><subject>Pilot Projects</subject><subject>Retina - metabolism</subject><subject>Supplementation</subject><subject>Xanthophylls - administration & dosage</subject><subject>Xanthophylls - blood</subject><subject>Xanthophylls - metabolism</subject><subject>Zeaxanthin</subject><subject>Zeaxanthins</subject><issn>0003-9861</issn><issn>1096-0384</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNp9kbuO1DAUhi0EYoeFB6BBrhAUCcdx4sSiGq2GizQSDSNtZznOCfEoN3xZGKp9hy14P56EzM5IbEVl2fr-7-j4J-Qlg5QBE-_2qa7rNAMQKcgUePaIrBhIkQCv8sdkBQA8kZVgF-SZ93sAxnKRPSUXrIQqr4CvyO9rPYZumrtD31NtTBxir4OdRmpHGjqkXRz0SB0GO2raRGfHb9THee5xwDGc0B82dLSPAZfM5Ogv1D-P1uX25_bu3rLdXW_W9M12d888nLk5IF0_mPuW-hCbw3PypNW9xxfn85LsPmy-Xn1Ktl8-fr5abxPDCxaSQnOZFSIHpttSmIYbXS9PPC9BlwWWUpoK6pYzVmayzqQWLTeZNsIYVhgj-CV5ffLObvoe0Qc1WG-w7_WIU_RKVLKSOcgFZCfQuMl7h62anR20OygG6tiG2qulDXVsQ4FUSxtL5tVZHusBm3-J8_cvwPsTgMuKNxad8sbiaLCxDk1QzWT_o_8LaUqePQ</recordid><startdate>20070215</startdate><enddate>20070215</enddate><creator>Schalch, Wolfgang</creator><creator>Cohn, William</creator><creator>Barker, Felix M.</creator><creator>Köpcke, Wolfgang</creator><creator>Mellerio, John</creator><creator>Bird, Alan C.</creator><creator>Robson, Anthony G.</creator><creator>Fitzke, Fred F.</creator><creator>van Kuijk, Frederik J.G.M.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070215</creationdate><title>Xanthophyll accumulation in the human retina during supplementation with lutein or zeaxanthin – the LUXEA (LUtein Xanthophyll Eye Accumulation) study</title><author>Schalch, Wolfgang ; Cohn, William ; Barker, Felix M. ; Köpcke, Wolfgang ; Mellerio, John ; Bird, Alan C. ; Robson, Anthony G. ; Fitzke, Fred F. ; van Kuijk, Frederik J.G.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c351t-5a39256401af76cd3caba393470a75e799c80bf311729b29a6f3c2ac6cc15cc63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>AMD</topic><topic>Carotenoids</topic><topic>Dietary Supplements</topic><topic>Double-Blind Method</topic><topic>Fovea</topic><topic>Heterochromatic Flicker Photometry</topic><topic>Humans</topic><topic>Lutein</topic><topic>Lutein - administration & dosage</topic><topic>Lutein - blood</topic><topic>Lutein - metabolism</topic><topic>Macula Lutea - chemistry</topic><topic>Macular pigment</topic><topic>Male</topic><topic>Middle Aged</topic><topic>OPTISHARP</topic><topic>Parafovea</topic><topic>Pilot Projects</topic><topic>Retina - metabolism</topic><topic>Supplementation</topic><topic>Xanthophylls - administration & dosage</topic><topic>Xanthophylls - blood</topic><topic>Xanthophylls - metabolism</topic><topic>Zeaxanthin</topic><topic>Zeaxanthins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schalch, Wolfgang</creatorcontrib><creatorcontrib>Cohn, William</creatorcontrib><creatorcontrib>Barker, Felix M.</creatorcontrib><creatorcontrib>Köpcke, Wolfgang</creatorcontrib><creatorcontrib>Mellerio, John</creatorcontrib><creatorcontrib>Bird, Alan C.</creatorcontrib><creatorcontrib>Robson, Anthony G.</creatorcontrib><creatorcontrib>Fitzke, Fred F.</creatorcontrib><creatorcontrib>van Kuijk, Frederik J.G.M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of biochemistry and biophysics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schalch, Wolfgang</au><au>Cohn, William</au><au>Barker, Felix M.</au><au>Köpcke, Wolfgang</au><au>Mellerio, John</au><au>Bird, Alan C.</au><au>Robson, Anthony G.</au><au>Fitzke, Fred F.</au><au>van Kuijk, Frederik J.G.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Xanthophyll accumulation in the human retina during supplementation with lutein or zeaxanthin – the LUXEA (LUtein Xanthophyll Eye Accumulation) study</atitle><jtitle>Archives of biochemistry and biophysics</jtitle><addtitle>Arch Biochem Biophys</addtitle><date>2007-02-15</date><risdate>2007</risdate><volume>458</volume><issue>2</issue><spage>128</spage><epage>135</epage><pages>128-135</pages><issn>0003-9861</issn><eissn>1096-0384</eissn><abstract>The xanthophylls lutein (L) and zeaxanthin (Z) form the macular pigment with the highest density in the
macula lutea. We investigated Macular Pigment Optical Density (MPOD) responses to supplementation with identically formulated (Actilease™) L or Z (OPTISHARP™) or L
+
Z over 6–12 months using doses of 10 or 20
mg/day. MPOD as well as blue light sensitivity in fovea and parafovea were measured monthly by heterochromatic flicker photometry. Average xanthophyll plasma concentrations, analysed monthly by HPLC, increased up to 27-fold. MPOD increased by 15% upon L or L
+
Z supplementation. Supplementation of Z alone produced similar pigment accumulation in fovea
and parafovea, which confounded MPOD measurements. After correction for this, a 14% MPOD increase resulted for Z. Thus, during supplementation with xanthophylls, L is predominantly deposited in the fovea while Z deposition appears to cover a wider retinal area. This may be relevant to health and disease of the retina.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>17084803</pmid><doi>10.1016/j.abb.2006.09.032</doi><tpages>8</tpages></addata></record> |
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subjects | Adolescent Adult AMD Carotenoids Dietary Supplements Double-Blind Method Fovea Heterochromatic Flicker Photometry Humans Lutein Lutein - administration & dosage Lutein - blood Lutein - metabolism Macula Lutea - chemistry Macular pigment Male Middle Aged OPTISHARP Parafovea Pilot Projects Retina - metabolism Supplementation Xanthophylls - administration & dosage Xanthophylls - blood Xanthophylls - metabolism Zeaxanthin Zeaxanthins |
title | Xanthophyll accumulation in the human retina during supplementation with lutein or zeaxanthin – the LUXEA (LUtein Xanthophyll Eye Accumulation) study |
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