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Xanthophyll accumulation in the human retina during supplementation with lutein or zeaxanthin – the LUXEA (LUtein Xanthophyll Eye Accumulation) study

The xanthophylls lutein (L) and zeaxanthin (Z) form the macular pigment with the highest density in the macula lutea. We investigated Macular Pigment Optical Density (MPOD) responses to supplementation with identically formulated (Actilease™) L or Z (OPTISHARP™) or L + Z over 6–12 months using doses...

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Published in:Archives of biochemistry and biophysics 2007-02, Vol.458 (2), p.128-135
Main Authors: Schalch, Wolfgang, Cohn, William, Barker, Felix M., Köpcke, Wolfgang, Mellerio, John, Bird, Alan C., Robson, Anthony G., Fitzke, Fred F., van Kuijk, Frederik J.G.M.
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cited_by cdi_FETCH-LOGICAL-c351t-5a39256401af76cd3caba393470a75e799c80bf311729b29a6f3c2ac6cc15cc63
cites cdi_FETCH-LOGICAL-c351t-5a39256401af76cd3caba393470a75e799c80bf311729b29a6f3c2ac6cc15cc63
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container_title Archives of biochemistry and biophysics
container_volume 458
creator Schalch, Wolfgang
Cohn, William
Barker, Felix M.
Köpcke, Wolfgang
Mellerio, John
Bird, Alan C.
Robson, Anthony G.
Fitzke, Fred F.
van Kuijk, Frederik J.G.M.
description The xanthophylls lutein (L) and zeaxanthin (Z) form the macular pigment with the highest density in the macula lutea. We investigated Macular Pigment Optical Density (MPOD) responses to supplementation with identically formulated (Actilease™) L or Z (OPTISHARP™) or L + Z over 6–12 months using doses of 10 or 20 mg/day. MPOD as well as blue light sensitivity in fovea and parafovea were measured monthly by heterochromatic flicker photometry. Average xanthophyll plasma concentrations, analysed monthly by HPLC, increased up to 27-fold. MPOD increased by 15% upon L or L + Z supplementation. Supplementation of Z alone produced similar pigment accumulation in fovea and parafovea, which confounded MPOD measurements. After correction for this, a 14% MPOD increase resulted for Z. Thus, during supplementation with xanthophylls, L is predominantly deposited in the fovea while Z deposition appears to cover a wider retinal area. This may be relevant to health and disease of the retina.
doi_str_mv 10.1016/j.abb.2006.09.032
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ispartof Archives of biochemistry and biophysics, 2007-02, Vol.458 (2), p.128-135
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source ScienceDirect Freedom Collection
subjects Adolescent
Adult
AMD
Carotenoids
Dietary Supplements
Double-Blind Method
Fovea
Heterochromatic Flicker Photometry
Humans
Lutein
Lutein - administration & dosage
Lutein - blood
Lutein - metabolism
Macula Lutea - chemistry
Macular pigment
Male
Middle Aged
OPTISHARP
Parafovea
Pilot Projects
Retina - metabolism
Supplementation
Xanthophylls - administration & dosage
Xanthophylls - blood
Xanthophylls - metabolism
Zeaxanthin
Zeaxanthins
title Xanthophyll accumulation in the human retina during supplementation with lutein or zeaxanthin – the LUXEA (LUtein Xanthophyll Eye Accumulation) study
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