Triamcinolone acetonide mouth rinses for treatment of erosive oral lichen planus: efficacy and risk of fungal over-infection

Objectives:  To assess the efficacy of triamcinolone acetonide mouthrinse for treatment of erosive oral lichen planus (OLP), and to evaluate the risk of fungal over‐infection. Patients and methods:  Clinical records of all cases of erosive and erosive‐ulcerative OLP treated in our Oral Medicine Serv...

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Bibliographic Details
Published in:Oral diseases 2006-11, Vol.12 (6), p.559-565
Main Authors: González-García, A, Diniz-Freitas, M, Gándara-Vila, P, Blanco-Carrión, A, García-García, A, Gándara-Rey, JM
Format: Article
Language:English
Subjects:
Adult
Aged
Candidiasis, Oral - etiology
Dentistry
Female
fungal infections
Glucocorticoids - administration & dosage
Glucocorticoids - therapeutic use
Humans
Lichen Planus, Oral - complications
Lichen Planus, Oral - drug therapy
Lichen Planus, Oral - pathology
Male
Middle Aged
Mouthwashes - therapeutic use
oral lichen planus
Retrospective Studies
Superinfection
topical corticoids
triamcinolone
Triamcinolone Acetonide - administration & dosage
Triamcinolone Acetonide - therapeutic use
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Summary:Objectives:  To assess the efficacy of triamcinolone acetonide mouthrinse for treatment of erosive oral lichen planus (OLP), and to evaluate the risk of fungal over‐infection. Patients and methods:  Clinical records of all cases of erosive and erosive‐ulcerative OLP treated in our Oral Medicine Service over the period 1993–2003 were reviewed. All patients had been treated with mouthrinses containing triamcinolone acetonide at 0.3% (T1) or 0.5% (T2). Clinical outcome for each patient was classified at 1, 3 and 6 months after start of treatment as total remission (TR), partial remission (PR) or no remission (NR). Fungal over‐infection was also recorded. Results:  A total of 35 cases were included in the study. Clinical outcomes considering both treatment groups together (T1 + T2) were as follows: at month 1, 28.6% TR, 62.9% PR, 8.6% NR; at month 3, 57.1% TR, 37.1% PR, 5.7% NR; and at month 6, 80.0% TR, 17.1% PR, 2.9% NR. In four patients (11.4%) fungal over‐infection was noted during the study period. Conclusion:  Triamcinolone acetonide mouthrinse is an appropriate treatment for erosive OLP, in view of the high efficacy and low risk of fungal over‐infection.
ISSN:1354-523X
1601-0825
DOI:10.1111/j.1601-0825.2006.01238.x