Meta-Analysis of Fractional Flow Reserve Versus Quantitative Coronary Angiography and Noninvasive Imaging for Evaluation of Myocardial Ischemia

We performed a meta-analysis of 31 studies comparing the results of fractional flow reserve (FFR) against quantitative coronary angiography (QCA) and/or noninvasive imaging of the same lesions. Studies were retrieved from PubMed (last search February 2006). Across 18 studies (1,522 lesions), QCA had...

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Bibliographic Details
Published in:The American journal of cardiology 2007-02, Vol.99 (4), p.450-456
Main Authors: Christou, Maria A.C, Siontis, George C.M, Katritsis, Demosthenes G., MD, PhD, Ioannidis, John P.A., MD
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blood Flow Velocity
Cardiology
Cardiology. Vascular system
Cardiovascular
Cardiovascular disease
Cardiovascular system
Coronary Angiography - methods
Coronary Circulation
Coronary heart disease
Diagnostic Imaging
Heart
Humans
Investigative techniques, diagnostic techniques (general aspects)
Medical imaging
Medical sciences
Meta-analysis
Myocardial Ischemia - diagnostic imaging
Myocarditis. Cardiomyopathies
Radiodiagnosis. Nmr imagery. Nmr spectrometry
ROC Curve
Sensitivity and Specificity
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Summary:We performed a meta-analysis of 31 studies comparing the results of fractional flow reserve (FFR) against quantitative coronary angiography (QCA) and/or noninvasive imaging of the same lesions. Studies were retrieved from PubMed (last search February 2006). Across 18 studies (1,522 lesions), QCA had a random effects sensitivity of 78% (95% confidence interval [CI] 67 to 86) and specificity of 51% (95% CI 40 to 61) against FFR (0.75 cutoff). Overall concordances were 61% for lesions with diameter stenosis 30% to 70%, 67% for stenoses >70%, and 95% for stenoses
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2006.09.092