Weight loss and non-alcoholic fatty liver disease: falls in gamma-glutamyl transferase concentrations are associated with histologic improvement

The ability for aminotransferase levels to track histological features of non-alcoholic fatty liver disease (NAFLD) with weight loss has not been examined. We examined the effect of weight loss following laparoscopic adjustable gastric banding surgery on the histological features of NAFLD and plasma...

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Bibliographic Details
Published in:Obesity surgery 2006-10, Vol.16 (10), p.1278-1286
Main Authors: Dixon, John B, Bhathal, Prithi S, O'Brien, Paul E
Format: Article
Language:English
Subjects:
Adult
Alanine Transaminase - blood
Aspartate Aminotransferases - blood
Comorbidity
Fatty Liver - blood
Fatty Liver - epidemiology
Fatty Liver - pathology
Fatty Liver - physiopathology
Female
Fibrosis
gamma-Glutamyltransferase - blood
Gastric Bypass
Humans
Liver - pathology
Male
Middle Aged
Obesity, Morbid - blood
Obesity, Morbid - epidemiology
Obesity, Morbid - surgery
Postoperative Period
Transaminases - blood
Weight control
Weight Loss - physiology
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Summary:The ability for aminotransferase levels to track histological features of non-alcoholic fatty liver disease (NAFLD) with weight loss has not been examined. We examined the effect of weight loss following laparoscopic adjustable gastric banding surgery on the histological features of NAFLD and plasma aminotransferase concentrations (AST, ALT and GGT) in 60 (12M, 48F) selected severely obese patients. All 120 paired biopsies were de-identified and scored for lobular steatosis, fibrosis, inflammation, Mallory bodies and NASH. 30 patients (50%) had baseline histological features of non-alcoholic steatohepatitis (NASH). Repeat biopsies were taken at 29.5+/-10 months after baseline. Mean weight loss was 31.5+/-18 kg. There were improvements in AST, ALT, GGT, lobular steatosis, inflammation and fibrosis between baseline and follow-up (P
ISSN:0960-8923
1708-0428
DOI:10.1381/096089206778663805