Corneal ulcer as an atypical presentation of ocular cicatricial pemphigoid

To describe three patients, each presenting noninfective corneal epithelial damage as first manifestation of ocular cicatricial pemphigoid (OCP). Case report. Patients 1 and 2 were referred to the authors' clinic for corneal ulcer while Patient 3 for relapsed epithelial defects. All patients ha...

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Bibliographic Details
Published in:European journal of ophthalmology 2007-01, Vol.17 (1), p.121-123
Main Authors: Sgrulletta, R, Lambiase, A, Micera, A, Bonini, S
Format: Article
Language:English
Subjects:
Administration, Topical
Adult
Conjunctiva - pathology
Corneal Ulcer - diagnosis
Corneal Ulcer - drug therapy
Epithelium, Corneal - pathology
Female
Fibrosis
Glucocorticoids - administration & dosage
Humans
Male
Middle Aged
Pemphigoid, Benign Mucous Membrane - diagnosis
Pemphigoid, Benign Mucous Membrane - drug therapy
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Summary:To describe three patients, each presenting noninfective corneal epithelial damage as first manifestation of ocular cicatricial pemphigoid (OCP). Case report. Patients 1 and 2 were referred to the authors' clinic for corneal ulcer while Patient 3 for relapsed epithelial defects. All patients had negative history for systemic diseases and microbiological tests were negative. Topical steroid treatment induced the complete resolution of corneal damage. During the follow-up period, the onset of mild conjunctival fibrosis in the lower fornix allowed the authors to suspect OCP, confirmed by conjunctival biopsy. In the three patients corneal damage was an early sign of OCP, in the absence of typical signs of conjunctival fibrosis. The authors thus suggest considering conjunctival biopsy as a useful additional test in the management of idiopathic corneal ulcers.
ISSN:1120-6721
1724-6016
DOI:10.1177/112067210701700117