Selenium alters the lipid content and protein profile of rat heart: An FTIR microspectroscopic study

Cardiovascular disease is one of the most important causes of morbidity and mortality in Western countries. In addition, it is well documented that selenium (Se) deficiency has been linked to cardiovascular diseases. This study was undertaken to present the effect of sodium selenite on left and righ...

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Bibliographic Details
Published in:Archives of biochemistry and biophysics 2007-02, Vol.458 (2), p.184-193
Main Authors: Toyran, Neslihan, Turan, Belma, Severcan, Feride
Format: Article
Language:English
Subjects:
Animals
Coronary Vessels - metabolism
Female
FTIR microspectroscopy
Heart
Heart - drug effects
Heart Ventricles - cytology
Heart Ventricles - drug effects
Heart Ventricles - metabolism
Lipid content
Lipid Metabolism - drug effects
Lipids - chemistry
Male
Myocardium
Myocardium - chemistry
Myocardium - metabolism
Protein structure
Protein Structure, Secondary
Proteins - chemistry
Proteins - metabolism
Rats
Rats, Wistar
Selenium
Sodium Selenite - pharmacology
Spectroscopy, Fourier Transform Infrared
Vein
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Summary:Cardiovascular disease is one of the most important causes of morbidity and mortality in Western countries. In addition, it is well documented that selenium (Se) deficiency has been linked to cardiovascular diseases. This study was undertaken to present the effect of sodium selenite on left and right myocardia, and small veins of normal control rat heart at molecular level by using Fourier transform infrared (FTIR) microspectroscopy. The results mainly reveal that, Se treatment causes an increase in lipid content both in the saturated and unsaturated lipids, and an alteration in protein profile with a decrease in α-helix and an increase in β-sheet structure of the rat heart which might be reflecting a slight subtoxic effect of selenium supplementation on normal rat heart at the dose used in this study.
ISSN:0003-9861
1096-0384
DOI:10.1016/j.abb.2006.12.012