Geographic and Racial/Ethnic Differences in HFE Mutation Frequencies In the Hemochromatosis and Iron Overload Screening (HEIRS) Study

To assess geographic differences in the frequencies of HFE C282Y and H63D genotypes in six racial/ethnic groups recruited in the Hemochromatosis and Iron Overload Screening (HEIRS) Study. HFE C282Y and H63D genotypes of 97,551 participants, ages > or = 25 years, who reported that they belonged to...

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Published in:Ethnicity & disease 2006-09, Vol.16 (4), p.815-821
Main Authors: Acton, Ronald T., Barton, James C., Snively, Beverly M., McLaren, Christine E., Adams, Paul C., Harris, Emily L., Speechley, Mark R., McLaren, Gordon D., Dawkins, Fitzroy W., Leiendecker-Foster, Catherine, Holup, Joan L., Balasubramanyam, Aarthi
Format: Article
Language:English
Subjects:
Adult
African Continental Ancestry Group - genetics
African Continental Ancestry Group - statistics & numerical data
Asian Continental Ancestry Group - genetics
Asian Continental Ancestry Group - statistics & numerical data
Continental Population Groups - genetics
Ethnic Groups - genetics
European Continental Ancestry Group - genetics
European Continental Ancestry Group - statistics & numerical data
Female
Gene Frequency
Genetic Predisposition to Disease
Genetic Testing
Genotype
Hemochromatosis - epidemiology
Hemochromatosis - ethnology
Hemochromatosis - genetics
Hemochromatosis Protein
Hispanic Americans - genetics
Hispanic Americans - statistics & numerical data
Histocompatibility Antigens Class I - genetics
Humans
Indians, North American - genetics
Indians, North American - statistics & numerical data
Iron Overload - epidemiology
Iron Overload - ethnology
Iron Overload - genetics
Male
Membrane Proteins - genetics
Mutation
North America - epidemiology
Oceanic Ancestry Group - genetics
Oceanic Ancestry Group - statistics & numerical data
Original Reports: Cardiovascular Disease and Related Risk Factors
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Summary:To assess geographic differences in the frequencies of HFE C282Y and H63D genotypes in six racial/ethnic groups recruited in the Hemochromatosis and Iron Overload Screening (HEIRS) Study. HFE C282Y and H63D genotypes of 97,551 participants, ages > or = 25 years, who reported that they belonged to one of six racial/ethnic groups, were analyzed. HFE genotype frequencies were compared among the racial/ethnic groups and among the HEIRS Study field centers within each racial/ethnic group. The distribution of HFE C282Y and H63D genotypes differed among racial/ethnic groups (P
ISSN:1049-510X