1p/19q chromosome deletions in metastatic oligodendroglioma

Extracranial metastasis of primary brain tumors is a rare phenomenon. Of the few cases reported of metastatic oligodendroglioma, only two have evaluated genetic alterations, specifically deletions of chromosomes 1p and 19q. Herein, we report two additional patients with metastatic anaplastic oligode...

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Bibliographic Details
Published in:Journal of neuro-oncology 2006-11, Vol.80 (2), p.203-207
Main Authors: MERRELL, Ryan, NABORS, L. Burton, PERRY, Arie, PALMER, Cheryl Ann
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Bone Marrow Neoplasms - genetics
Bone Marrow Neoplasms - secondary
Bone Neoplasms - genetics
Bone Neoplasms - secondary
Brain Neoplasms - pathology
Chromosome Deletion
Chromosomes, Human, Pair 1 - genetics
Chromosomes, Human, Pair 19 - genetics
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Fatal Outcome
Female
Humans
In Situ Hybridization
Magnetic Resonance Imaging
Male
Medical sciences
Nervous system (semeiology, syndromes)
Nervous system as a whole
Neurology
Oligodendroglioma - genetics
Oligodendroglioma - secondary
Spinal Neoplasms - genetics
Spinal Neoplasms - secondary
Tomography, X-Ray Computed
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Summary:Extracranial metastasis of primary brain tumors is a rare phenomenon. Of the few cases reported of metastatic oligodendroglioma, only two have evaluated genetic alterations, specifically deletions of chromosomes 1p and 19q. Herein, we report two additional patients with metastatic anaplastic oligodendroglioma to bone, both followed until death. All available pathology specimens were reviewed and genetic analysis was performed in one of the cases. Although the bone metastasis was non-informative, the primary intracranial tumor revealed codeletions of the 1p and 19q chromosomal arms, commonly recognized as the genetically favorable profile of oligodendrogliomas. Both patients died of complications related to their systemic disease and did not have any radiologic evidence of intracranial progression at the time of their last MRI studies. Along with the reported literature, our data suggest that despite their generally favorable behavioral profiles, oligodendroglial tumors with 1p/19q deletions may be more prone to metastasis as they progress. Genetic analysis serves a valuable ancillary role in the diagnostic workup of such cases.
ISSN:0167-594X
1573-7373
DOI:10.1007/s11060-006-9179-0