Cyclopentanone ring-cleaved pleuromutilin derivatives

Ring-cleaved pleuromutilin derivatives comprised of a [5.3.1] bicyclic core structure have been synthesized and evaluated in vitro as antibacterial agents. Four of the compounds described were found to have MICs ≤ 4 μg/mL against marker strains of Streptococcus pneumoniae and Staphylococcus aureus....

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Bibliographic Details
Published in:European journal of medicinal chemistry 2007, Vol.42 (1), p.109-113
Main Authors: Springer, Dane M., Bunker, Amy, Luh, Bing-Yu, Sorenson, Margaret E., Goodrich, Jason T., Bronson, Joanne J., DenBleyker, Kenneth, Dougherty, Thomas J., Fung-Tomc, Joan
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Diterpenes - chemical synthesis
Diterpenes - chemistry
Diterpenes - pharmacology
Medical sciences
Microbial Sensitivity Tests
Pharmacology. Drug treatments
Pleuromutilins
Polycyclic Compounds
Staphylococcus aureus - drug effects
Streptococcus pneumoniae - drug effects
Structure-Activity Relationship
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Summary:Ring-cleaved pleuromutilin derivatives comprised of a [5.3.1] bicyclic core structure have been synthesized and evaluated in vitro as antibacterial agents. Four of the compounds described were found to have MICs ≤ 4 μg/mL against marker strains of Streptococcus pneumoniae and Staphylococcus aureus. [Display omitted] Antibacterial pleuromutilin derivatives containing a bicyclic nucleus are described.
ISSN:0223-5234
1768-3254
DOI:10.1016/j.ejmech.2006.07.018