Evaluation of antioxidant activity of Ginkgo biloba phytosomes in rat brain

Ginkgo biloba from the traditional Chinese system of medicine has been found to possess neurocognitive enhancing effects. The mechanism of action of Ginkgo seems to be related to its antioxidant properties. In the present study, Ginkgo biloba phytosomes were administered to Wistar rats at 50 mg/kg a...

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Published in:Phytotherapy research 2006-11, Vol.20 (11), p.1013-1016
Main Authors: Naik, Suresh R., Pilgaonkar, Vinaya W., Panda, Vandana S.
Format: Article
Language:English
Subjects:
Animals
antioxidant
Antioxidants - pharmacology
Biological and medical sciences
Brain - drug effects
Brain - enzymology
Drugs, Chinese Herbal - pharmacology
Female
General pharmacology
Ginkgo biloba
Ginkgo biloba - chemistry
Male
Medical sciences
neurocognitive
Oxidoreductases - analysis
Oxidoreductases - drug effects
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
phytosomes
Plant Extracts - pharmacology
Rats
Rats, Wistar
Sodium Nitrite - administration & dosage
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Summary:Ginkgo biloba from the traditional Chinese system of medicine has been found to possess neurocognitive enhancing effects. The mechanism of action of Ginkgo seems to be related to its antioxidant properties. In the present study, Ginkgo biloba phytosomes were administered to Wistar rats at 50 mg/kg and 100 mg/kg for 7 and 14 days. Chemical hypoxia was induced by administration of sodium nitrite (75 mg/kg) 1 h after the last administration of treatment. Thirty minutes after sodium nitrite administration, the animals were killed and the cerebral cortex, cerebellum, hippocampus and striatum were isolated and homogenized. The supernatants were used for the estimation of the antioxidant enzymes superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase. Ginkgo biloba phytosome treatment was found to increase superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase activities in all the brain regions compared with those treated only with sodium nitrite. The prevention of depletion of the antioxidant enzymes by sodium nitrite in the presence of Ginkgo biloba phytosomes may be correlated to its antioxidant activity. Copyright © 2006 John Wiley & Sons, Ltd.
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.1976