Extract of Pelargonium sidoides (EPs ® 7630) inhibits the interactions of group A-streptococci and host epithelia in vitro

EPs ® 7630 is an extract of the root of the South African geranium Pelargonium sidoides. Clinical data have shown that this herbal drug preparation can be used to treat upper respiratory tract infections (URTI). The objective of this study was to investigate the impact of EPs ® 7630 on group A-strep...

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Bibliographic Details
Published in:Phytomedicine (Stuttgart) 2007-02, Vol.14 (2-3), p.52-59
Main Authors: Conrad, Andreas, Jung, Irina, Tioua, Diane, Lallemand, Caroline, Carrapatoso, Felipe, Engels, Inge, Daschner, Franz D., Frank, Uwe
Format: Article
Language:English
Subjects:
Adhesion
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Bacteria
Bacterial Adhesion - drug effects
Bacterial Adhesion - physiology
Cell research
Cells, Cultured
Dose-Response Relationship, Drug
Epithelial Cells - physiology
EPs ® 7630
Geraniums
Group A-streptococci (GAS)
Health aspects
Humans
Invasion
Medicine, Botanic
Medicine, Herbal
Microbial Sensitivity Tests
Pelargonium
Pelargonium sidoides
Phytotherapy
Plant Extracts - administration & dosage
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Plant Roots
Prevention
Respiratory tract infections
Respiratory Tract Infections - drug therapy
Streptococcus pyogenes - drug effects
Streptococcus pyogenes - physiology
Upper respiratory tract infections (URTI)
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Summary:EPs ® 7630 is an extract of the root of the South African geranium Pelargonium sidoides. Clinical data have shown that this herbal drug preparation can be used to treat upper respiratory tract infections (URTI). The objective of this study was to investigate the impact of EPs ® 7630 on group A-streptococci (GAS) adhering to and invading host epithelial cells in vitro. Adhesion was assessed by a flow cytometric adhesion assay using calcein-AM-stained S. pyogenes (DSM 2071) as test organism, and HEp-2 cells and buccal epithelial cells (BEC) as substrata. For cell invasion, HEp-2 cell monolayers were infected with S. pyogenes. Intracellular bacteria were determined using a penicillin/gentamicin-protection assay. EPs ® 7630 was applied in therapeutically relevant concentrations between 0 and 30 μg/ml in both test systems. Compared to controls, EPs ® 7630 significantly reduced GAS adhesion to HEp-2 cells in a concentration-dependent manner by up to 46% ( p
ISSN:0944-7113
1618-095X
DOI:10.1016/j.phymed.2006.11.018