Predictors of idiopathic thrombocytopenic purpura in pregnant women presenting with thrombocytopenia

Abstract Objective Idiopathic thrombocytopenic purpura (ITP) and gestational thrombocytopenia (GT) are common causes of thrombocytopenia during pregnancy. Despite an ever-increasing experience with these disorders, differentiation between the two entities still remains a diagnostic challenge. The cu...

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Bibliographic Details
Published in:International journal of gynecology and obstetrics 2007-02, Vol.96 (2), p.85-88
Main Authors: Kwon, J.Y, Shin, J.C, Lee, J.W, Lee, J.K, Kim, S.P, Rha, J.G
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Female
Gestational Age
Gestational thrombocytopenia
Gynecology. Andrology. Obstetrics
Hematologic and hematopoietic diseases
Humans
Idiopathic thrombocytopenic purpura
Medical sciences
Obstetrics and Gynecology
Platelet Count
Platelet diseases and coagulopathies
Predictor
Pregnancy
Pregnancy Complications, Hematologic - physiopathology
Prognosis
Purpura, Thrombocytopenic, Idiopathic - etiology
Retrospective Studies
Thrombocytopenia - complications
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Summary:Abstract Objective Idiopathic thrombocytopenic purpura (ITP) and gestational thrombocytopenia (GT) are common causes of thrombocytopenia during pregnancy. Despite an ever-increasing experience with these disorders, differentiation between the two entities still remains a diagnostic challenge. The current study attempted to identify the antenatal predictors of ITP for pregnant women. Methods Between January 1999 and June 2005, a total of 58 pregnant women with a presumptive diagnosis of either ITP or GT were recruited for the study. All of them had platelet counts of less than 100 × 109 /L. The predictors of ITP were evaluated by comparison between the two disorders. Results The detection of thrombocytopenia prior to 28 weeks of gestation and platelet counts < 50 × 109 /L at its diagnosis remained independently predictive of ITP ( P < 0.001 and P = 0.004, respectively). The combined analysis of these two factors provided a 96.0% sensitivity and a specificity of 75.8%. Conclusion The onset time of thrombocytopenia and platelet count at its presentation remain the strongest predictors of ITP for pregnant women. The combination model using these factors may be useful for the early prediction of ITP.
ISSN:0020-7292
1879-3479
DOI:10.1016/j.ijgo.2006.09.021