Cytotoxic Hypothemycin Analogues from Hypomyces subiculosus

Three new hypothemycin analogues were isolated from the fungal strains Hypomyces subiculosus DSM 11931 and DSM 11932. The structures of these compounds were elucidated by spectroscopic methods, chemical conversion, and X-ray crystallographic analysis. One of the analogues, 4-O-demethylhypothemycin,...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2006-10, Vol.69 (10), p.1456-1459
Main Authors: Wee, Janice L, Sundermann, Kurt, Licari, Peter, Galazzo, Jorge
Format: Article
Language:English
Subjects:
anticarcinogenic activity
Antineoplastic Agents - chemistry
Antineoplastic Agents - isolation & purification
Antineoplastic Agents - pharmacology
Ascomycota - chemistry
Biological and medical sciences
Cell Line, Tumor
chemical structure
Crystallography, X-Ray
cultured cells
cytotoxicity
demethylhypothemycin
Drug Screening Assays, Antitumor
General pharmacology
Humans
Hypomyces
Hypomyces subiculosus
hypothemycin
Medical sciences
Molecular Structure
Mutation
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
spectral analysis
X-ray diffraction
zearalenone
Zearalenone - analogs & derivatives
Zearalenone - chemistry
Zearalenone - isolation & purification
Zearalenone - pharmacology
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Summary:Three new hypothemycin analogues were isolated from the fungal strains Hypomyces subiculosus DSM 11931 and DSM 11932. The structures of these compounds were elucidated by spectroscopic methods, chemical conversion, and X-ray crystallographic analysis. One of the analogues, 4-O-demethylhypothemycin, exhibited potent and selective cytotoxic activity against cell lines with a BRAF mutation.
ISSN:0163-3864
1520-6025
DOI:10.1021/np060258o