A Review: Synthesis of Aryl C-Glycosides Via the Heck Coupling Reaction

In this article, we focus on the synthesis of aryl C-glycosides via Heck coupling. It is organized based on the type of structures used in the assembly of the C-glycosides (also called C-nucleosides) with the following subsections: pyrimidine C-nucleosides, purine C-nucleosides, and monocyclic, bicy...

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Bibliographic Details
Published in:Nucleosides, nucleotides & nucleic acids nucleotides & nucleic acids, 2006-01, Vol.25 (12), p.1309-1333
Main Authors: Wellington, Kevin W., Benner, Steven A.
Format: Article
Language:English
Subjects:
Chemistry - methods
Cytokines - chemistry
Genetic Techniques
Glycosides - chemical synthesis
Glycosides - chemistry
Models, Chemical
Nucleic Acid Conformation
Nucleosides - chemistry
Pyrimidines - chemistry
Reverse Transcriptase Inhibitors - pharmacology
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Summary:In this article, we focus on the synthesis of aryl C-glycosides via Heck coupling. It is organized based on the type of structures used in the assembly of the C-glycosides (also called C-nucleosides) with the following subsections: pyrimidine C-nucleosides, purine C-nucleosides, and monocyclic, bicyclic, and tetracyclic C-nucleosides. The reagents and conditions used for conducting the Heck coupling reactions are discussed. The subsequent conversion of the Heck products to the corresponding target molecules and the application of the target molecules are also described.
ISSN:1525-7770
1532-2335
DOI:10.1080/15257770600917013