Carcinoma in situ cervicis uteri and inheritance—A Danish twin study

To determine the relative environmental and genetic influence in the development of carcinoma in situ (CIS) cervicis uteri. Retrospective follow-up study with record linkage between The Danish Twin Register and The Danish Cancer Register. The study base comprises 27,004 female twins from 13,502 same...

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Bibliographic Details
Published in:Gynecologic oncology 2006-11, Vol.103 (2), p.688-691
Main Authors: Thomsen, Louise Schmidt Arenholt, Jochumsen, Kirsten Marie, Mogensen, Ole
Format: Article
Language:English
Subjects:
Adult
Carcinoma in Situ - epidemiology
Carcinoma in Situ - genetics
Carcinoma in situ cervicis uteri
Cohort Studies
Denmark - epidemiology
Environment
Female
Genetic
Humans
Incidence
Inheritance
Registries
Twin study
Twins
Uterine Cervical Neoplasms - epidemiology
Uterine Cervical Neoplasms - genetics
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Summary:To determine the relative environmental and genetic influence in the development of carcinoma in situ (CIS) cervicis uteri. Retrospective follow-up study with record linkage between The Danish Twin Register and The Danish Cancer Register. The study base comprises 27,004 female twins from 13,502 same-sex twin pairs. 5258 were monozygotic and 8244 dizygotic twin pairs. The statistic measurements are the coincidence ratio and the probandwise concordance rate in the two groups of twins with different zygosity. 750 twins were diagnosed with CIS cervicis uteri. 291 monozygotic twins came from 275 pairs and 459 dizygotic twins came from 435 pairs. There were 16 concordant monozygotic twin pairs and 24 concordant dizygotic pairs. The probandwise concordance rate was 0.11 (0.06–0.16) in monozygotic twins and 0.10 (0.06–0.14) in dizygotic twins. A family clustering of CIS was demonstrated in both groups of zygosity. The probandwise concordance rate was equal in the monozygotic and the dizygotic groups, which means that genetic factors are not important in the development of the disease. However, a shared environment among twins plays a role in the development of CIS cervicis uteri.
ISSN:0090-8258
1095-6859
DOI:10.1016/j.ygyno.2006.05.008