Conformational Control of Transmembrane Cl- Transport

Preorganization of the isophthalamide cleft in N,N‘-dibutyl-4,6-dihydroxyisophthalamide (2) by means of intramolecular hydrogen bonds results in an enhanced anion receptor that displays significant chloride transport activity into EYPC liposomes. This function is easily switchable by controlling the...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2007-02, Vol.129 (7), p.1886-1887
Main Authors: Santacroce, Paul V, Davis, Jeffery T, Light, Mark E, Gale, Philip A, Iglesias-Sánchez, José Carlos, Prados, Pilar, Quesada, Roberto
Format: Article
Language:English
Subjects:
Amides - chemistry
Amides - metabolism
Chlorides - chemistry
Chlorides - metabolism
Crystallography, X-Ray
Hydrogen Bonding
Ion Transport
Lipid Bilayers - chemistry
Lipid Bilayers - metabolism
Liposomes - chemistry
Models, Molecular
Molecular Conformation
Organic Anion Transporters - chemistry
Organic Anion Transporters - metabolism
Phthalic Acids - chemistry
Phthalic Acids - metabolism
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Summary:Preorganization of the isophthalamide cleft in N,N‘-dibutyl-4,6-dihydroxyisophthalamide (2) by means of intramolecular hydrogen bonds results in an enhanced anion receptor that displays significant chloride transport activity into EYPC liposomes. This function is easily switchable by controlling the pH.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja068067v