Expression of EMMPRIN and matriptase in esophageal squamous cell carcinoma: Correlation with clinicopathological parameters

• Published in: Diseases of the esophagus 2006-12, Vol.19 (6), p.482-486
• Main Authors: Cheng, M.-F., Tzao, C., Tsai, W.-C., Lee, W.-H., Chen, A., Chiang, H., Sheu, L.-F., Jin, J.-S.
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Basigin - genetics; Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - pathology; CD147; Cell Differentiation; Disease Progression; EMMPRIN; Esophageal Neoplasms - metabolism; Esophageal Neoplasms - pathology; esophagus; Female; Humans; Immunohistochemistry; Male; matriptase; Middle Aged; Oligonucleotide Array Sequence Analysis; Serine Endopeptidases - metabolism; squamous cell carcinoma
• ISSN: 1120-8694; 1442-2050
• DOI: 10.1111/j.1442-2050.2006.00613.x

Extracellular matrix metalloproteinase inducer (EMMPRIN) and the type II transmembrane serine protease, matriptase, are expressed in several human cancers and play an important role in tumor progression. The aim of the present study was to investigate the immuno‐staining patterns of EMMPRIN and matriptase in patients with esophageal squamous cell carcinomas (SCC) and correlate the percentage tumor staining with tumor differentiation and clinical parameters. EMMPRIN and matriptase immunoreactivity was seen on the cell membrane and in the cytoplasm of tumor cells in all 41 cases of esophageal SCC evaluated. The percentage tumor staining of EMMPRIN was 48 ± 3% for well differentiated, 73 ± 3% for moderately differentiated, and 92 ± 3% for poorly differentiated esophageal SCC. Higher percentage tumor staining with EMMPRIN correlated significantly with poorly differentiated esophageal SCC (P