Is spinal cord isolation a good model of muscle disuse?

The patterns of normal daily activity that are required to maintain normal skeletal muscle properties remain unknown. The present study was designed to determine whether spinal cord isolation can be used as a reliable experimental model of neuromuscular inactivity, that is, as a baseline for the abs...

Full description

Saved in:
Bibliographic Details
Published in:Muscle & nerve 2007-03, Vol.35 (3), p.312-321
Main Authors: Roy, R. R., Zhong, H., Khalili, N., Kim, S. J., Higuchi, N., Monti, R. J., Grossman, E., Hodgson, J. A., Edgerton, V. R.
Format: Article
Language:English
Subjects:
Action Potentials - physiology
Animals
Biological and medical sciences
Disease Models, Animal
Disease Progression
diurnal activity cycles
Electrodiagnosis. Electric activity recording
Electromyography
Female
Fundamental and applied biological sciences. Psychology
inactivity
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Muscle Contraction - physiology
Muscle Fibers, Fast-Twitch - physiology
Muscle Fibers, Slow-Twitch - physiology
Muscle, Skeletal - innervation
Muscle, Skeletal - physiopathology
Muscular Disorders, Atrophic - physiopathology
Nervous system
Rats
Rats, Sprague-Dawley
Rhizotomy - methods
skeletal muscle activation
skeletal muscle recruitment
Spinal Cord Injuries - physiopathology
Spinal Nerve Roots - injuries
Spinal Nerve Roots - physiology
Spinal Nerve Roots - physiopathology
Striated muscle. Tendons
Vertebrates: osteoarticular system, musculoskeletal system
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The patterns of normal daily activity that are required to maintain normal skeletal muscle properties remain unknown. The present study was designed to determine whether spinal cord isolation can be used as a reliable experimental model of neuromuscular inactivity, that is, as a baseline for the absence of activity. Electromyograms (EMGs) were recorded from selected hindlimb muscles of unanesthetized rats over 24‐hour periods before and 7, 30, 60, and 90 days after surgical isolation of the lumbar spinal cord. Our data indicate that some rat slow muscle fibers pre‐surgery were activated for less than 3 hours per day. Spinal cord isolation (SI) reduced the mean daily integrated EMG (IEMG) and daily EMG duration in the primary slow extensor muscle (soleus) to
ISSN:0148-639X
1097-4598
DOI:10.1002/mus.20706