Increased serum soluble CD40 levels in patients with systemic sclerosis

OBJECTIVE: To determine serum levels of soluble CD40 (sCD40) and clinical association in patients with systemic sclerosis (SSc). METHODS: Serum sCD40 levels were examined by ELISA in 49 patients with SSc, 15 patients with systemic lupus erythematosus, and 26 healthy individuals. sCD40 levels in plas...

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Published in:Journal of rheumatology 2007-02, Vol.34 (2), p.353-358
Main Authors: KOMURA, Kazuhiro, FUJIMOTO, Manabu, MATSUSHITA, Takashi, YANABA, Koichi, KODERA, Masanari, KAWASUJI, Ayako, HASEGAWA, Minoru, TAKEHARA, Kazuhiko, SATO, Shinichi
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Biological and medical sciences
Biomarkers - blood
CD40 Antigens - blood
Child
Child, Preschool
Enzyme-Linked Immunosorbent Assay
Female
Humans
Longitudinal Studies
Lupus Erythematosus, Systemic - blood
Male
Medical sciences
Middle Aged
Plasma
Retrospective Studies
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Scleroderma, Diffuse - blood
Scleroderma, Diffuse - pathology
Scleroderma, Limited - blood
Scleroderma, Limited - pathology
Skin - pathology
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Summary:OBJECTIVE: To determine serum levels of soluble CD40 (sCD40) and clinical association in patients with systemic sclerosis (SSc). METHODS: Serum sCD40 levels were examined by ELISA in 49 patients with SSc, 15 patients with systemic lupus erythematosus, and 26 healthy individuals. sCD40 levels in plasma samples, which were obtained at the same time, were also determined. SSc patients were grouped into 22 patients with limited cutaneous SSc (lcSSc) and 27 patients with diffuse cutaneous SSc (dcSSc). RESULTS: There was no significant difference between sCD40 levels of sera and those of plasma. Serum sCD40 levels were significantly elevated in patients with SSc compared to patients with systemic lupus erythematosus and controls (p < 0.001). Serum sCD40 levels were higher in patients with lcSSc than in those with dcSSc (p
ISSN:0315-162X
1499-2752