Graft-vs.-host disease in lung and other solid organ transplant recipients

:  Graft‐vs.‐host disease (GVHD) is an uncommon complication of solid organ transplantation. Herein, we report a case of GVHD occurring in a lung transplant recipient and review 29 reported cases of GVHD that complicated thoracic organ, and non‐hepatic intra‐abdominal organ transplantation. The majo...

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Bibliographic Details
Published in:Clinical transplantation 2007-01, Vol.21 (1), p.1-6
Main Authors: Assi, Maha A, Pulido, Jose S, Peters, Steve G, McCannel, Colin A, Razonable, Raymund R
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
chorioretinopathy
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Graft vs Host Disease - epidemiology
graft-vs.-host
graft-vs.-host disease
Humans
Lung Transplantation - adverse effects
Male
Medical sciences
Ophthalmology
Organ Transplantation - adverse effects
Prednisone - therapeutic use
Retinopathies
solid organ transplant
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Tissue, organ and graft immunology
Treatment Outcome
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Summary::  Graft‐vs.‐host disease (GVHD) is an uncommon complication of solid organ transplantation. Herein, we report a case of GVHD occurring in a lung transplant recipient and review 29 reported cases of GVHD that complicated thoracic organ, and non‐hepatic intra‐abdominal organ transplantation. The major presenting clinical symptom of GVHD was skin rash. Less frequent clinical manifestations were cytopenia (16%), diarrhea (11%), and fever (5%). The mainstay of treatment was high‐dose corticosteroids. The mortality rate was high (30%). The cause of death was mainly due to infection, suggesting that antimicrobial prophylaxis may improve the outcome of this potentially fatal complication.
ISSN:0902-0063
1399-0012
DOI:10.1111/j.1399-0012.2006.00573.x