Agreement between two devices for measuring exhaled nitric oxide

Measurement of fractional exhaled nitric oxide (FENO) is a non-invasive marker of eosinophilic airway inflammation that can be useful in asthma diagnosis and control, as well as in treatment monitoring. We studied the correlation between two techniques for measuring FENO: the chemiluminescence-based...

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Bibliographic Details
Published in:Anales de pediatría (Barcelona, Spain : 2003) Spain : 2003), 2007-12, Vol.67 (6), p.572-577
Main Authors: Sardón Prado, O, Aldasoro Ruiz, A, Korta Murua, J, Mintegui Aramburu, J, Emparanza Knorr, J I, Pérez-Yarza, E G
Format: Article
Language:Spanish
Subjects:
Adolescent
Adult
Breath Tests - instrumentation
Child
Cross-Sectional Studies
Electrochemistry
Equipment Design
Exhalation
Female
Humans
Luminescent Measurements
Male
Nitric Oxide - analysis
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Summary:Measurement of fractional exhaled nitric oxide (FENO) is a non-invasive marker of eosinophilic airway inflammation that can be useful in asthma diagnosis and control, as well as in treatment monitoring. We studied the correlation between two techniques for measuring FENO: the chemiluminescence-based analyzer (NIOX, Aerocrine, Sweden) and a new portable electrochemical sensor-based analyzer (NIOX-MINO, Aerocrine). FENO was measured by the single breath on-line method. In all children, three consecutives measurements were obtained with NIOX, with a maximum of six attempts, and the arithmetic mean was calculated. Next, using NIOX-MINO, a single measurement was made successively in each of the children. The variables analyzed were sex, age, height, weight, diagnosis, treatment, NIOX-MINO value, mean of three values obtained with NIOX and the NO elimination rate (nL/min). For the statistical analysis, the Bland-Altman plot was used to compare the means and the differences between measurements of FENO from NIOX and NIOX-MINO. The agreement between the two analyzers was estimated by Cohen's Kappa statistic. Thirty children were included, 14 (46.67%) boys and 16 (53.33%) girls. The mean age was 11.3+/-3.09 years. All of the children successfully performed the measurements with two analyzers. The relationship between the means and the differences in the values obtained with NIOX-MINO and NIOX were statistically significant (p
ISSN:1695-4033